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loading...| Preferred Name |
Oteracil |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C76917 |
| CAS_Registry |
937-13-3 |
| CHEBI_ID |
CHEBI:30863 |
| Chemical_Formula |
C4H3N3O4 |
| code |
C76917 |
| Concept_In_Subset | |
| Contributing_Source |
FDA |
| DEFINITION |
A modulator of 5-fluorouracil (5-FU) activity and inhibitor of the enzyme orotate phosphoribosyl-transferase (OPRT), with chemoprotective activity. Oteracil preferentially localizes in the gastrointestinal (GI) tract where it inhibits OPRT, thereby decreasing metabolism of 5-FU into its active metabolite 5-fluorouridine-5'-monophosphate (FUMP). This decreases activated 5-FU-related gastrointestinal toxicity. |
| FDA_UNII_Code |
5VT6420TIG |
| FULL_SYN |
OTERACIL Oxonic Acid Oteracil |
| label |
Oteracil |
| Legacy Concept Name |
Oteracil |
| Preferred_Name |
Oteracil |
| prefixIRI |
Thesaurus:C76917 |
| prefLabel |
Oteracil |
| Semantic_Type |
Pharmacologic Substance |
| UMLS_CUI |
C0030032 |
| subClassOf |
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