loading...| Preferred Name |
Fumagillin-Derived Polymer Conjugate XMT-1107 |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C88321 |
| code |
C88321 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 |
| Contributing_Source |
CTRP GDC |
| DEFINITION |
A polymeric prodrug consisting of the fumagillol-derived small molecule XMT-1191 tethered to the hydrophilic, biodegradable70 kDa polymer poly[1-hydroxymethylethylene hydroxymethylformal] (PHF) with potential antiangiogenic and antineoplastic activities. Upon administration, fumagillin-derived polymer conjugate XMT-1107 releases XMT-1191, which may inhibit angiogenesis through the irreversible inhibition of the methionine aminopeptidase 2 (METAP2); although the exact mechanism of action has yet to be fully elucidated, this agent appears to induce cell cycle arrest in endothelial cells, inhibiting their proliferation and migration. Compared to an unconjugated fumagillin analog, XMT-1107 exhibits improved solubility and an extended half life due to its PHF backbone. METAP2, a member of the methionyl aminopeptidase family, binds two cobalt or manganese ions and protects the alpha subunit of eukaryotic initiation factor 2 (EIF2) from inhibitory phosphorylation by removing the amino-terminal methionine residue from nascent protein; this aminopeptidase may be overexpressed in a variety of tumor cell types. |
| Display_Name |
Fumagillin-Derived Polymer Conjugate XMT-1107 |
| FULL_SYN |
XMT-1107 Fumagillin-Derived Polymer Conjugate XMT-1107 |
| Has_Target | |
| Is_Value_For_GDC_Property | |
| label |
Fumagillin-Derived Polymer Conjugate XMT-1107 |
| Maps_To |
Fumagillin-Derived Polymer Conjugate XMT-1107 |
| NCI_Drug_Dictionary_ID |
660895 |
| NCI_META_CUI |
CL413581 |
| PDQ_Closed_Trial_Search_ID |
660895 |
| PDQ_Open_Trial_Search_ID |
660895 |
| Preferred_Name |
Fumagillin-Derived Polymer Conjugate XMT-1107 |
| prefixIRI |
Thesaurus:C88321 |
| prefLabel |
Fumagillin-Derived Polymer Conjugate XMT-1107 |
| Semantic_Type |
Pharmacologic Substance |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| There are currently no mappings for this class. | |||