Choline Kinase Alpha Inhibitor TCD-717

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C94213

850993-73-6

C94213

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

CTRP

GDC

FDA

A small-molecule inhibitor of choline kinase alpha (CHKA), with potential antineoplastic activity. TCD-717 targets and binds to CHKA, an enzyme that plays a key role in the synthesis of phosphatidylcholine, the major phospholipid in eukaryotic cell membranes. Blockade of this enzyme induces cells to activate a different route for phospholipid production which causes a toxic effect and eventually leads to cell destruction. CHKA, overexpressed in human cancer cells while only minimally expressed in normal cells, appears to play a significant role in cellular proliferation, evasion of apoptosis, increased cell motility and metastasis.

Choline Kinase Alpha Inhibitor TCD-717

KC1UXA6R4Z

RSM-932A

TCD-717

CHKA Inhibitor TCD-717

Choline Kinase Alpha Inhibitor TCD-717

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25920

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909

Choline Kinase Alpha Inhibitor TCD-717

Choline Kinase Alpha Inhibitor TCD-717

687183

CL426026

687183

687183

Choline Kinase Alpha Inhibitor TCD-717

Thesaurus:C94213

Choline Kinase Alpha Inhibitor TCD-717

Pharmacologic Substance

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C471