loading...| Preferred Name |
Opaganib |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98278 |
| CAS_Registry |
915385-81-8 |
| code |
C98278 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 |
| Contributing_Source |
CTRP GDC FDA |
| DEFINITION |
An orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. Upon administration, opaganib competitively binds to and inhibits SK2, thereby preventing the phosphorylation of the pro-apoptotic amino alcohol sphingosine to sphingosine 1-phosphate (S1P), the lipid mediator that is pro-survival and critical for immunomodulation. This may eventually lead to the induction of apoptosis and may result in an inhibition of cell proliferation in cancer cells overexpressing SK2. SK2 and its isoenzyme SK1 are overexpressed in numerous cancer cell types. |
| Display_Name |
Opaganib |
| FDA_UNII_Code |
DRG21OQ517 |
| FULL_SYN |
ABC294640 Tricyclo(3.3.1.13,7)decane-1-carboxamide, 3-(4-Chlorophenyl)-N-(4-pyridinylmethyl)- OPAGANIB Opaganib ABC 294640 4-Pyridinylmethyl-3-(4-chlorophenyl) Adamantane Carboxamide SK2 inhibitor ABC294640 Yeliva |
| Has_Target | |
| Is_Value_For_GDC_Property | |
| label |
Opaganib |
| Maps_To |
Opaganib |
| NCI_Drug_Dictionary_ID |
712053 |
| PDQ_Closed_Trial_Search_ID |
712053 |
| PDQ_Open_Trial_Search_ID |
712053 |
| Preferred_Name |
Opaganib |
| prefixIRI |
Thesaurus:C98278 |
| prefLabel |
Opaganib |
| Semantic_Type |
Pharmacologic Substance |
| UMLS_CUI |
C2933331 |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| There are currently no mappings for this class. | |||