loading...| Preferred Name |
Glutamate Decarboxylase |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C193255 |
| ALT_DEFINITION |
Any antigen(s) encoded by the GAD gene that catalyze the decarboxylation of glutamate to GABA. They can be considered as autoantigens and are commonly associated with the autoimmune diseases type 1 diabetes, autoimmune polyendocrine syndrome types 1 and 2, and stiff man syndrome. |
| code |
C193255 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66830 |
| Contributing_Source |
CDISC |
| DEFINITION |
A lyase that catalyzes the decarboxylation of glutamate to gamma-aminobutyric acid (GABA) and carbon dioxide (CO2), which uses pyridoxal-phosphate (PLP) as a cofactor. There are two human isoforms of glutamate decarboxylase that are responsible for maintaining the majority of the physiological supply of GABA. |
| FULL_SYN |
GLUTAMIC ACID DECARBOXYLASE Glutamic Acid Decarboxylase Glutamate Decarboxylase EC 4.1.1.15 GAD |
| label |
Glutamate Decarboxylase |
| Preferred_Name |
Glutamate Decarboxylase |
| prefixIRI |
Thesaurus:C193255 |
| prefLabel |
Glutamate Decarboxylase |
| Semantic_Type |
Enzyme Amino Acid, Peptide, or Protein |
| subClassOf |