loading...| Preferred Name |
Interleukin-12 |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20514 |
| code |
C20514 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 |
| Contributing_Source |
CTRP |
| DEFINITION |
Exhibiting a broad range of biological activities on T and natural killer cells, Interleukin-12 is a disulfide-bonded heterodimeric cytokine composed of a 35-kD IL12A subunit (IL-6 Superfamily) and a 40-kDa IL12B subunit (Type I Cytokine Receptor 3 Family). IL12 stimulates T-cell-independent production of IFN-gamma by PBMCs, enhances NK cell lytic activity, acts as a growth factor for T- and NK-cells, and is important for Th1 and Th2 cell differentiation. Lymphocyte responses to IL12 require NOS2A and are mediated by STAT4 activator of transcription. (NCI) |
| Display_Name |
Interleukin-12 |
| FULL_SYN |
CLMF Interleukin-12 IL-12p70 Natural Killer Cell Stimulatory Factor IL-12 NKSF IL12 Cytotoxic Lymphocyte Maturation Factor IL-12 p70 Interleukin 12 |
| label |
Interleukin-12 |
| Legacy Concept Name |
Interleukin-12 |
| Preferred_Name |
Interleukin-12 |
| prefixIRI |
Thesaurus:C20514 |
| prefLabel |
Interleukin-12 |
| Semantic_Type |
Immunologic Factor Amino Acid, Peptide, or Protein |
| UMLS_CUI |
C0123759 |
| subClassOf |