Sulfonylurea Antidiabetic Agent

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97936

C97936

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

GDC

Sulfonamide urea derivatives with antihyperglycemic activity. Sulphonylurea antidiabetic agents bind to sulfonylurea receptor type 1 (SUR1), the subunit of ATP-sensitive inwardly-rectifier potassium (IKATP) channels on the membranes of pancreatic beta cells, thereby blocking the inward current flow (influx) of positively charged K+ ions into the cell. This results in tonic membrane depolarization, and induces a calcium ion influx through voltage-sensitive calcium channels; increased intracellular calcium ion levels trigger exocytosis of insulin-containing granules. This eventually induces secretion of insulin. The IKATP channels found in pancreatic islets are complexes of four IKATP 6.2 and four SUR1 subunits. In addition, some sulfonylureas of larger molecular size may increase the sensitivity of peripheral tissues to insulin mediated through peroxisome proliferator-activated receptor gamma (PPARgamma).

Sulfonylurea

Sulfonylurea Antidiabetic Agent

Sulphonylurea Antidiabetic Agent

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C99532

Sulfonylurea Antidiabetic Agent

Sulfonylurea

Sulfonylurea Antidiabetic Agent

Thesaurus:C97936

Sulfonylurea Antidiabetic Agent

Chemical Viewed Functionally

C3273710

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29711