Preferred Name

P-Selectin

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17522

code

C17522

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142800

Contributing_Source

CTRP

DEFINITION

P-selectin (830 aa, ~91 kDa) is encoded by the human SELP gene. This protein plays a role in leukocyte adhesion to myeloid cells, endothelial cells or platelets.

DesignNote

P-Selectin is a cell surface adhesion molecule that mediates the interaction of activated endothelial cells or platelets with neutrophils and monocytes. The protein is detected in megakaryocytes and platelets, as well as in vascular endothelial cells, but not in other cell types. In endothelia, the protein is localized to the membranes of Weibel-Palade bodies, intracellular storage granules for von Willebrand factor. CD24 is a ligand for P-selectin. Sorting nexin-17 interacts with the cytosolic domain of P-selectin and may function in the intracellular trafficking of P-selectin.

Display_Name

P-Selectin

FULL_SYN

GMP-140

CD62P Antigen

LECAM3

SELP

Granulocyte Membrane Protein

P-Selectin

CD62 Antigen-Like Family Member P

Leukocyte-Endothelial Cell Adhesion Molecule 3

Platelet Activation Dependent Granule-External Membrane Protein

GMP140

Granule Membrane Protein 140

CD62

Platelet Alpha-Granule Membrane Protein

PADGEM

label

P-Selectin

Legacy Concept Name

P-Selectin

OMIM_Number

173610

Preferred_Name

P-Selectin

prefixIRI

Thesaurus:C17522

prefLabel

P-Selectin

Semantic_Type

Amino Acid, Peptide, or Protein

Swiss_Prot

P16109

UMLS_CUI

C2742134

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16393

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http://purl.bioontology.org/ontology/MESH/D019007 Medical Subject Headings / 医学主题词表 LOOM
http://purl.org/sig/ont/fma/fma62933 Foundational Model of Anatomy / 解剖学基础模型本体 LOOM