| Preferred Name |
P-Selectin |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17522 |
| code |
C17522 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 |
| Contributing_Source |
CTRP |
| DEFINITION |
P-selectin (830 aa, ~91 kDa) is encoded by the human SELP gene. This protein plays a role in leukocyte adhesion to myeloid cells, endothelial cells or platelets. |
| DesignNote |
P-Selectin is a cell surface adhesion molecule that mediates the interaction of activated endothelial cells or platelets with neutrophils and monocytes. The protein is detected in megakaryocytes and platelets, as well as in vascular endothelial cells, but not in other cell types. In endothelia, the protein is localized to the membranes of Weibel-Palade bodies, intracellular storage granules for von Willebrand factor. CD24 is a ligand for P-selectin. Sorting nexin-17 interacts with the cytosolic domain of P-selectin and may function in the intracellular trafficking of P-selectin. |
| Display_Name |
P-Selectin |
| FULL_SYN |
GMP-140 CD62P Antigen LECAM3 SELP Granulocyte Membrane Protein P-Selectin CD62 Antigen-Like Family Member P Leukocyte-Endothelial Cell Adhesion Molecule 3 Platelet Activation Dependent Granule-External Membrane Protein GMP140 Granule Membrane Protein 140 CD62 Platelet Alpha-Granule Membrane Protein PADGEM |
| label |
P-Selectin |
| Legacy Concept Name |
P-Selectin |
| OMIM_Number |
173610 |
| Preferred_Name |
P-Selectin |
| prefixIRI |
Thesaurus:C17522 |
| prefLabel |
P-Selectin |
| Semantic_Type |
Amino Acid, Peptide, or Protein |
| Swiss_Prot |
P16109 |
| UMLS_CUI |
C2742134 |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.bioontology.org/ontology/MESH/D019007 | Medical Subject Headings / 医学主题词表 | LOOM | |
| http://purl.org/sig/ont/fma/fma62933 | Foundational Model of Anatomy / 解剖学基础模型本体 | LOOM |