Preferred Name

RNA Polymerase III Transcription Pathway

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C39225

ALT_DEFINITION

Unlike the RNA polymerase II that transcribes a large variety of genes that encode proteins, RNA polymerase III transcribes only a limited number of genes (i.e., 5S rRNA, tRNA, 7SL RNA, U6 snRNA, and a few other small stable RNAs); however, the transcriptional activities of RNA pol III along with pol I account for 80% of total RNA synthesis. The A and B block sequences found in most pol III promoters are recognized by a multisubunit complex, TFIIIC. The binding of TFIIIC recruits TFIIIB, a complex of polypeptides (in human, TATA-binding protein (TBP), TFIIB-related factor (BRF), and one or more unidentified protein). Once TFIIIB is brought to the general location by TFIIIC and optimally positioned by TBP, the transcription initiates about 30bp downstream. The transcription process requires the melting of dsDNA and participation of TFIIIB. Unlike pol I and II, pol III termination occurs efficiently at four or more T residues without other protein factors. La protein can stimulate the release of RNA and pol III transcription; however, deletion of La has no apparent effect on pol III activity. (This definition may be outdated - see the DesignNote.)

BioCarta_ID

h_RNApol3Pathway

code

C39225

DesignNote

The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.

FULL_SYN

RNA Polymerase III Transcription Pathway

RNA polymerase III transcription

label

RNA Polymerase III Transcription Pathway

Legacy Concept Name

RNA_Polymerase_III_Transcription_Pathway

Preferred_Name

RNA Polymerase III Transcription Pathway

prefixIRI

Thesaurus:C39225

prefLabel

RNA Polymerase III Transcription Pathway

Semantic_Type

Functional Concept

UMLS_CUI

C1514668

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C39736

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http://purl.obolibrary.org/obo/PW_0000128 Pathway Ontology / 通路本体 LOOM