Mismatch Repair Pathway

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C91471

DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preventing mutations from becoming permanent in dividing cells. MMR also suppresses homologous recombination and was recently shown to play a role in DNA damage signaling. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including HNPCC, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems.

C91471

DNA Mismatch Repair Pathway

Mismatch Repair Pathway

Mismatch repair

hsa03430

Mismatch Repair Pathway

Mismatch Repair Pathway

Thesaurus:C91471

Mismatch Repair Pathway

Functional Concept

C2984283

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C39705