megakaryoblastic acute myeloid leukemia with t(1;22)(p13;q13)

megakaryoblastic AML with t(1;22)(p13;q13)

Megakaryoblastic acute myeloid leukemia with t(1;22)(p13;q13) is a rare subtype of acute myeloid leukemia with recurrent cytogenetic abnormalities characterized by clonal proliferation of myeloid blasts with predominantly megakaryoblastic differentiation in the bone marrow and blood, often with extensive infiltration of the abdominal organs. It occurs typically in infants and usually presents with hepatosplenomegaly, anemia, thrombocytopenia and nonspecific symptoms related to ineffective hematopoesis (fatigue, bleeding and bruising, recurrent infections). Myelofibrosis and fibrosis of other infiltrated organs is also characteristic of this disease.

http://purl.obolibrary.org/obo/MONDO_0018436

Orphanet:402023

SCTID:763796007

Megakaryoblastic acute myeloid leukemia with t(1;22)(p13;q13) is a rare subtype of acute myeloid leukemia with recurrent cytogenetic abnormalities characterized by clonal proliferation of myeloid blasts with predominantly megakaryoblastic differentiation in the bone marrow and blood, often with extensive infiltration of the abdominal organs. It occurs typically in infants and usually presents with hepatosplenomegaly, anemia, thrombocytopenia and nonspecific symptoms related to ineffective hematopoesis (fatigue, bleeding and bruising, recurrent infections). Myelofibrosis and fibrosis of other infiltrated organs is also characteristic of this disease.

http://identifiers.org/snomedct/763796007

http://purl.obolibrary.org/obo/Orphanet_402023

megakaryoblastic AML with t(1;22)(p13;q13)

MONDO:0018436

http://purl.obolibrary.org/obo/mondo#ordo_disease

megakaryoblastic acute myeloid leukemia with t(1;22)(p13;q13)

MONDO:0018436

megakaryoblastic acute myeloid leukemia with t(1;22)(p13;q13)

http://purl.obolibrary.org/obo/MONDO_0018874

http://purl.obolibrary.org/obo/MONDO_0018874