loading...| Preferred Name |
amyotrophic lateral sclerosis pathway |
| Synonyms |
ALS pathway KEGG:05014 amyotrophic lateral sclerosis disease pathway |
| Definitions |
A late onset, mostly sporadic neurodegenerative disease characterized by the loss of motor neurons in the brain stem and spinal cord. Various pathways are thought to be deregulated and contribute to the condition; among them calcium and/or zinc homeostasis, apoptosis, Cdk5 and calcineurin dependent processes, and in the case of the more rare, genetically inherited form of the disease, mutations in the cytosolic Cu, Zn superoxide dismutase (SOD1) and the subsequent changes in the processes that involve SOD1. |
| ID |
http://purl.obolibrary.org/obo/PW_0000016 |
| definition |
A late onset, mostly sporadic neurodegenerative disease characterized by the loss of motor neurons in the brain stem and spinal cord. Various pathways are thought to be deregulated and contribute to the condition; among them calcium and/or zinc homeostasis, apoptosis, Cdk5 and calcineurin dependent processes, and in the case of the more rare, genetically inherited form of the disease, mutations in the cytosolic Cu, Zn superoxide dismutase (SOD1) and the subsequent changes in the processes that involve SOD1. |
| has_exact_synonym |
ALS pathway amyotrophic lateral sclerosis disease pathway |
| has_obo_namespace |
pathway |
| has_related_synonym |
KEGG:05014 |
| id |
PW:0000016 |
| label |
amyotrophic lateral sclerosis pathway |
| notation |
PW:0000016 |
| prefLabel |
amyotrophic lateral sclerosis pathway |
| treeView | |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38782 | National Cancer Institute Thesaurus / 美国国家癌症研究所词典 | LOOM |