loading...| Preferred Name |
integrin mediated signaling pathway |
| Synonyms |
Integrin signaling integrin-mediated signaling pathway |
| Definitions |
Integrins signal bi-directionally across the plasma membrane and provide an example of mechanotransduction. Inside-out signaling modulates their interaction with ligands to regulate cell adhesion and ECM organization. Ligand binding initiates and shapes many signaling events and links to the cytoskeleton. Via protein clustering and ECM organization integrins synergize with and/or modulate various growth factor pathways. Integrin signaling regulates multiple processes including gene expression, cell proliferation, differentiation and survival. |
| ID |
http://purl.obolibrary.org/obo/PW_0000286 |
| definition |
Integrins signal bi-directionally across the plasma membrane and provide an example of mechanotransduction. Inside-out signaling modulates their interaction with ligands to regulate cell adhesion and ECM organization. Ligand binding initiates and shapes many signaling events and links to the cytoskeleton. Via protein clustering and ECM organization integrins synergize with and/or modulate various growth factor pathways. Integrin signaling regulates multiple processes including gene expression, cell proliferation, differentiation and survival. |
| has_obo_namespace |
pathway |
| has_related_synonym |
Integrin signaling integrin-mediated signaling pathway |
| id |
PW:0000286 |
| label |
integrin mediated signaling pathway |
| notation |
PW:0000286 |
| prefLabel |
integrin mediated signaling pathway |
| treeView | |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.obolibrary.org/obo/GO_0007229 | Gene Ontology / 基因本体 | LOOM |