Preferred Name |
Hippo signaling pathway |
Synonyms |
Signaling by Hippo hippo signaling |
Definitions |
The Hippo signaling pathway plays important roles in organ development and growth and tumor suppression. The pathway consists of a core of four kinases which once activated by upstream regulators promote the cytoplasmic sequestration of YAP/TAZ transcriptional regulators. Dysregulation of the pathway has been implicated in tumor metastasis. |
ID |
http://purl.obolibrary.org/obo/PW_0001515 |
created_by |
VPetri |
creation_date |
2014-03-19T11:27:29Z |
definition |
The Hippo signaling pathway plays important roles in organ development and growth and tumor suppression. The pathway consists of a core of four kinases which once activated by upstream regulators promote the cytoplasmic sequestration of YAP/TAZ transcriptional regulators. Dysregulation of the pathway has been implicated in tumor metastasis. |
has_obo_namespace |
pathway |
has_related_synonym |
Signaling by Hippo hippo signaling |
id |
PW:0001515 |
label |
Hippo signaling pathway |
notation |
PW:0001515 |
prefLabel |
Hippo signaling pathway |
treeView | |
subClassOf |
Delete | Mapping To | Ontology | Source |
---|---|---|---|
http://purl.bioontology.org/ontology/MESH/D000090683 | Medical Subject Headings / 医学主题词表 | LOOM |