Preferred Name |
RNase_P_RNA |
Synonyms |
INSDC_feature:ncRNA INSDC_qualifier:RNase_P_RNA RNase P RNA |
Definitions |
The RNA component of Ribonuclease P (RNase P), a ubiquitous endoribonuclease, found in archaea, bacteria and eukarya as well as chloroplasts and mitochondria. Its best characterized activity is the generation of mature 5 prime ends of tRNAs by cleaving the 5 prime leader elements of precursor-tRNAs. Cellular RNase Ps are ribonucleoproteins. RNA from bacterial RNase Ps retains its catalytic activity in the absence of the protein subunit, i.e. it is a ribozyme. Isolated eukaryotic and archaeal RNase P RNA has not been shown to retain its catalytic function, but is still essential for the catalytic activity of the holoenzyme. Although the archaeal and eukaryotic holoenzymes have a much greater protein content than the bacterial ones, the RNA cores from all the three lineages are homologous. Helices corresponding to P1, P2, P3, P4, and P10/11 are common to all cellular RNase P RNAs. Yet, there is considerable sequence variation, particularly among the eukaryotic RNAs. Moved under enzymatic_RNA on 18 Nov 2021. See GitHub Issue #533. |
ID |
http://purl.obolibrary.org/obo/SO_0000386 |
comment |
Moved under enzymatic_RNA on 18 Nov 2021. See GitHub Issue #533. |
definition |
The RNA component of Ribonuclease P (RNase P), a ubiquitous endoribonuclease, found in archaea, bacteria and eukarya as well as chloroplasts and mitochondria. Its best characterized activity is the generation of mature 5 prime ends of tRNAs by cleaving the 5 prime leader elements of precursor-tRNAs. Cellular RNase Ps are ribonucleoproteins. RNA from bacterial RNase Ps retains its catalytic activity in the absence of the protein subunit, i.e. it is a ribozyme. Isolated eukaryotic and archaeal RNase P RNA has not been shown to retain its catalytic function, but is still essential for the catalytic activity of the holoenzyme. Although the archaeal and eukaryotic holoenzymes have a much greater protein content than the bacterial ones, the RNA cores from all the three lineages are homologous. Helices corresponding to P1, P2, P3, P4, and P10/11 are common to all cellular RNase P RNAs. Yet, there is considerable sequence variation, particularly among the eukaryotic RNAs. |
has_broad_synonym |
INSDC_feature:ncRNA |
has_exact_synonym |
INSDC_qualifier:RNase_P_RNA RNase P RNA |
has_obo_namespace |
sequence |
id |
SO:0000386 |
in_subset | |
label |
RNase_P_RNA |
notation |
SO:0000386 |
prefLabel |
RNase_P_RNA |
subClassOf |
Delete | Mapping To | Ontology | Source |
---|---|---|---|
http://purl.obolibrary.org/obo/SO_0000386 | MicroRNA Ontology / MicroRNA本体 | LOOM | |
http://purl.obolibrary.org/obo/SO_0000386 | MicroRNA Ontology / MicroRNA本体 | SAME_URI |