loading...| Preferred Name |
Proteasome Inhibitor |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2160 |
| ALT_DEFINITION |
A drug that blocks the action of proteasomes. A proteasome is a large protein complex that helps destroy other cellular proteins when they are no longer needed. Proteasome inhibitors are being studied in the treatment of cancer. |
| CHEBI_ID |
CHEBI:52726 |
| code |
C2160 |
| DEFINITION |
Any substance that inhibits the proteasome complex, an enzyme complex responsible for degradation of ubiquitinated proteins. Inhibition of proteasome activity and ubiquitin-proteasome mediated proteolysis results in an accumulation of poly-ubiquitinated proteins, which may result in the disruption of cellular processes, cell cycle arrest, the induction of apoptosis, and the inhibition of tumor growth and angiogenesis. |
| FULL_SYN |
proteasome inhibitor Proteasome Inhibitor |
| label |
Proteasome Inhibitor |
| Legacy Concept Name |
Proteasome_Inhibitor |
| Preferred_Name |
Proteasome Inhibitor |
| prefixIRI |
Thesaurus:C2160 |
| prefLabel |
Proteasome Inhibitor |
| Semantic_Type |
Chemical Viewed Functionally |
| UMLS_CUI |
C1443643 |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.obolibrary.org/obo/CHEBI_52726 | Chemical Entities of Biological Interest Ontology / 生物相关的化学实体本体 | LOOM | |
| http://purl.obolibrary.org/obo/CHEBI_52726 | The Drug Ontology / 药物本体 | LOOM |