loading...| Preferred Name |
plecanatide |
| Synonyms |
L-leucine, L-asparaginyl-L-alpha-aspartyl-L-alpha-glutamyl-L-cysteinyl-L-alpha-glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (4-12),(7-15)-bis(disulfide) |
| ID |
http://purl.bioontology.org/ontology/MESH/C584575 |
| altLabel |
L-leucine, L-asparaginyl-L-alpha-aspartyl-L-alpha-glutamyl-L-cysteinyl-L-alpha-glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (4-12),(7-15)-bis(disulfide) SP-304 Trulance |
| cui |
C4310275 C3711911 C3468004 |
| HM |
D045265 |
| II |
D050705/Q000819 |
| Inverse of RB |
7IK8Z952OK |
| isa | |
| LT |
TRD |
| Mapped to | |
| MDA |
20131124 |
| MeSH Frequency |
36 |
| MMR |
20170929 |
| notation |
C584575 |
| PA |
D000074268 D005765 |
| prefLabel |
plecanatide |
| SC |
1 |
| Scope Statement |
A uroguanylin analog and guanylate cyclase (GC-C receptor) agonist that activates receptors on gut epithelial cells to maintain barrier function, mucus production, and suppress inflammation. It is used in the treatment of chronic idiopathic constipation and other gastrointestinal disorders. |
| SRC |
Dig Dis Sci. 2013 Sep;58(9):2580-6. |
| TERMUI |
T851364 T000914574 T000914587 |
| TH |
NLM (2017) FDA SRS (2017) USAN (19XX) NLM (2014) INN (19XX) |
| tui |
T109 T121 |