loading...| Preferred Name |
Cilastatin, Imipenem Drug Combination |
| Synonyms |
Imipenem-Cilastatin, Sodium Salt |
| Definitions |
Combination of imipenem and cilastatin that is used in the treatment of bacterial infections; cilastatin inhibits renal dehydropeptidase I to prolong the half-life and increase the tissue penetration of imipenem, enhancing its efficacy as an anti-bacterial agent. |
| ID |
http://purl.bioontology.org/ontology/MESH/D000077728 |
| altLabel |
Imipenem-Cilastatin, Sodium Salt Imipenem Cilastatin Sodium Imipenem-Cilastatin Imipenem - Cilastatin Sodium Zienam Imipenem Cilastatin, Sodium Salt Thienam MK 787-MK 791 mixture Cilastatin, Imipenem Imipenem-Cilastatin Sodium Primaxin MK 0787-MK 0791 mixture MK 0787 MK 0791 mixture MK 787 MK 791 mixture Tienam 500 Imipenem - Cilastatin Imipenem Cilastatin |
| AQL |
AA AD AE AG AI AN BL CF CH CL CS EC HI IM IP ME PD PK PO RE SD ST TO TU UR |
| cui |
C0071972 C0733696 C0733698 C0145923 C0145617 C0733701 C0733695 |
| DC |
1 |
| definition |
Combination of imipenem and cilastatin that is used in the treatment of bacterial infections; cilastatin inhibits renal dehydropeptidase I to prolong the half-life and increase the tissue penetration of imipenem, enhancing its efficacy as an anti-bacterial agent. |
| DX |
20190101 |
| HN |
2019 (1985) |
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000528 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000031 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000378 |
| Inverse of RB |
92309-29-0 85960-17-4 0 |
| isa | |
| LT |
TRD |
| Machine permutation |
2019; CILASTATIN, IMIPENEM DRUG COMBINATION was indexed under CILASTATIN and IMIPENEM 1995-2018 and 1988-1994; under DRUG COMBINATIONS 1995-2018 and 1985-1994; and under CYCLOPROPANES and THIENAMYCINS 1985-1988 |
| MDA |
20180709 |
| MMR |
20180410 |
| MN |
D02.455.426.392.368.533.200.500 D10.251.355.325.200.500 D02.065.589.099.124.300.500.500 D03.633.100.300.124.300.500.500 D26.310.356 |
| notation |
D000077728 |
| PA |
D011480 D000900 |
| prefLabel |
Cilastatin, Imipenem Drug Combination |
| RR |
85960-17-4 (Na salt) |
| TERMUI |
T160282 T160286 T000940945 T000940940 T000941293 T000940943 T160281 T160285 T160283 T000940941 T000940944 T000940942 T160284 T000941292 |
| TH |
US NLM (1985) NLM (2009) CA NLM (2010) AU NLM (2019) UK |
| tui |
T109 T195 T121 |
| subClassOf |
http://purl.bioontology.org/ontology/MESH/D015377 |