loading...| Preferred Name |
Hypereosinophilic syndrome |
| Synonyms |
hypereosinophilic syndrome Idiopathic Hypereosinophilic Syndrome Loeffler's Endocarditis hypereosinophilic disorder eosinophilic leukocytosis Loeffler Endocarditis hypereosinophilic disease HES eosinophilia |
| Definitions |
The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil count (≥ 1500 eosinophils/mm³) in the blood for at least six months without any recognizable cause, with involvement of either the heart, nervous system, or bone marrow. HES is a diagnosis of exclusion, after clonal eosinophilia (such as leukemia) and reactive eosinophilia (in response to infection, autoimmune disease, atopy, hypoadrenalism, tropical eosinophilia, or cancer) have been ruled out. Hypereosinophilic syndrome (HES) constitutes a rare and heterogeneous group of disorders, defined as persistent and marked blood eosinophilia and/or tissue eosinophilia associated with a wide range of clinical manifestations reflecting eosinophil-induced tissue/organ damage. |
| ID |
http://www.ebi.ac.uk/efo/EFO_1001467 |
| closeMatch | |
| database_cross_reference |
ICDO:9964/3 GARD:0002804 MESH:D017681 DOID:999 MONDO:0015691 MedDRA:10048643 ORDO:Orphanet_168956 Orphanet:168956 MeSH:D017681 SCTID:419455006 NCIT:C27038 ICD9:288.3 Wikipedia:Hypereosinophilic_syndrome UMLS:C1540912 |
| definition |
The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil count (≥ 1500 eosinophils/mm³) in the blood for at least six months without any recognizable cause, with involvement of either the heart, nervous system, or bone marrow. HES is a diagnosis of exclusion, after clonal eosinophilia (such as leukemia) and reactive eosinophilia (in response to infection, autoimmune disease, atopy, hypoadrenalism, tropical eosinophilia, or cancer) have been ruled out. Hypereosinophilic syndrome (HES) constitutes a rare and heterogeneous group of disorders, defined as persistent and marked blood eosinophilia and/or tissue eosinophilia associated with a wide range of clinical manifestations reflecting eosinophil-induced tissue/organ damage. |
| disease has feature | |
| exactMatch |
http://purl.obolibrary.org/obo/DOID_999 http://linkedlifedata.com/resource/umls/id/C1540912 http://purl.obolibrary.org/obo/NCIT_C27038 http://identifiers.org/mesh/D017681 |
| has_exact_synonym |
hypereosinophilic syndrome Idiopathic Hypereosinophilic Syndrome Loeffler's Endocarditis hypereosinophilic disorder eosinophilic leukocytosis Loeffler Endocarditis hypereosinophilic disease HES |
| has_related_synonym |
eosinophilia |
| id |
EFO:1001467 |
| in_subset |
http://purl.obolibrary.org/obo/mondo#ordo_group_of_disorders |
| label |
Hypereosinophilic syndrome |
| notation |
EFO:1001467 |
| prefLabel |
Hypereosinophilic syndrome |
| term editor |
Gautier Koscielny |
| subClassOf |
http://www.orpha.net/ORDO/Orphanet_158300 http://www.ebi.ac.uk/efo/EFO_1001473 http://purl.obolibrary.org/obo/MONDO_0002254 |