loading...| Preferred Name |
Thromboxane A2 |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C122988 |
| CAS_Registry |
57576-52-0 |
| CHEBI_ID |
CHEBI:15627 |
| code |
C122988 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 |
| Contributing_Source |
CTRP FDA |
| DEFINITION |
An eicosanoid and short-lived intermediate product between prostaglandin endoperoxides and thromboxane B2, with prothrombotic and vasoconstrictive activities. Thromboxane A (TXA2) binds to its cognate receptor thromboxane A2 receptor (TBXA2R) and stimulates increased expression of glycoprotein IIb/IIIa (GPIIb/IIIa) on platelet membranes, which induces platelet activation and aggregation. Circulating fibrinogen binds to GPIIb/IIIa on platelet surfaces, which promotes clotting. TXA2 also binds to TBXA2R expressed by glomerular cells, which induces signaling pathways that promote vasoconstriction. |
| Display_Name |
Thromboxane A2 |
| FDA_UNII_Code |
4C2A5G825S |
| FULL_SYN |
9S,11S-Epoxy,15S-Hydroxy-Thromboxa-5Z,13E-Dien-1-Oic Acid Thromboxa-5,13-Dien-1-Oic Acid, 9,11-Epoxy-15-Hydroxy-, (5Z,9alpha,11alpha,13E,15S)- 5-Heptenoic Acid, 7-(3-(3-Hydroxy-1-Octenyl)-2,6-Dioxabicyclo(3.1.1)Hept-4-Yl)-, (1S-(1alpha,3alpha,3R*),4beta(Z),5alpha)- (5Z,9alpha,11alpha,13E,15S)-9,11-Epoxy-15-Hydroxythromboxa-5,13-Dien-1-Oic Acid TXA2 (5Z,13E)-(15S)-9alpha,11alpha-Epoxy-15-Hydroxythromboxa-5,13-Dienoate (5Z,13E,15S)-9alpha,11alpha-Epoxy-15-Hydroxythromboxa-5,13-Dien-1-Oic Acid TXA-2 THROMBOXANE A2 Thromboxane A2 |
| label |
Thromboxane A2 |
| Preferred_Name |
Thromboxane A2 |
| prefixIRI |
Thesaurus:C122988 |
| prefLabel |
Thromboxane A2 |
| Semantic_Type |
Organic Chemical |
| UMLS_CUI |
C0040057 |
| subClassOf |