loading...| Preferred Name |
methiothepin |
| Synonyms |
metitepina (+-)-8-Methylthio-10-(4-methylpiperazino)-10,11-dihydrodibenzo(b,f)thiepin metitepine 1-methyl-4-[8-(methylthio)-10,11-dihydrodibenzo[b,f]thiepin-10-yl]piperazine (+-)-1-(10,11-Dihydro-8-(methylthio)dibenzo(b,f)thiepin-10-yl)-4-methylpiperazine 1-methyl-4-[8-(methylsulfanyl)-10,11-dihydrodibenzo[b,f]thiepin-10-yl]piperazine metitepinum 1-(10,11-Dihydro-8-(methylthio)dibenzo(b,f)thiepin-10-yl)-4-methylpiperazine (+-)-10-(4-Methylpiperazinyl)-8-(methylthio)-10,11-dihydrodibenzo(b,f)thiepin Methiothepine |
| Definitions |
A dibenzothiepine that is 10,11-dihydrodibenzo[b,f]thiepine bearing additional methylthio and 4-methylpiperazin-1-yl substituents at positions 8 and 10 respectively. Potent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays affinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively). |
| ID |
http://purl.obolibrary.org/obo/CHEBI_64203 |
| charge |
0 |
| database_cross_reference |
PMID:21964383 Patent:US3379729 Patent:NL6608618 Wikipedia:Metitepine HMDB:HMDB0254534 PMID:19837141 PMID:20547148 CAS:20229-30-5 PMID:19995401 PMID:18996971 PMID:18033297 LINCS:LSM-4320 Patent:US4444778 PMID:21062995 PMID:20171242 Patent:US6331536 PMID:21514998 PMID:20331882 PMID:21403818 PMID:20233210 Reaxys:626221 |
| definition |
A dibenzothiepine that is 10,11-dihydrodibenzo[b,f]thiepine bearing additional methylthio and 4-methylpiperazin-1-yl substituents at positions 8 and 10 respectively. Potent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays affinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively). |
| formula |
C20H24N2S2 |
| has role |
http://purl.obolibrary.org/obo/CHEBI_48279 http://purl.obolibrary.org/obo/CHEBI_48561 |
| has_exact_synonym |
1-methyl-4-[8-(methylsulfanyl)-10,11-dihydrodibenzo[b,f]thiepin-10-yl]piperazine |
| has_obo_namespace |
chebi_ontology |
| has_related_synonym |
metitepina (+-)-8-Methylthio-10-(4-methylpiperazino)-10,11-dihydrodibenzo(b,f)thiepin metitepine 1-methyl-4-[8-(methylthio)-10,11-dihydrodibenzo[b,f]thiepin-10-yl]piperazine (+-)-1-(10,11-Dihydro-8-(methylthio)dibenzo(b,f)thiepin-10-yl)-4-methylpiperazine metitepinum 1-(10,11-Dihydro-8-(methylthio)dibenzo(b,f)thiepin-10-yl)-4-methylpiperazine (+-)-10-(4-Methylpiperazinyl)-8-(methylthio)-10,11-dihydrodibenzo(b,f)thiepin Methiothepine |
| id |
CHEBI:64203 |
| in_subset | |
| inchi |
InChI=1S/C20H24N2S2/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20/h3-8,14,18H,9-13H2,1-2H3 |
| inchikey |
RLJFTICUTYVZDG-UHFFFAOYSA-N |
| is conjugate base of | |
| label |
methiothepin |
| mass |
356.54800 |
| monoisotopicmass |
356.13809 |
| notation |
CHEBI:64203 |
| prefLabel |
methiothepin |
| smiles |
CSc1ccc2Sc3ccccc3CC(N3CCN(C)CC3)c2c1 |
| treeView |
http://purl.obolibrary.org/obo/CHEBI_50996 http://purl.obolibrary.org/obo/CHEBI_46845 |
| subClassOf |
http://purl.obolibrary.org/obo/CHEBI_50996 http://purl.obolibrary.org/obo/CHEBI_46845 |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.bioontology.org/ontology/MESH/D008719 | Medical Subject Headings / 医学主题词表 | LOOM |