loading...| Preferred Name |
Platelet Factor 4 |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20811 |
| code |
C20811 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 |
| Contributing_Source |
CTRP |
| DEFINITION |
Platelet factor 4 (101 aa, ~11 kDa) is encoded by the human PF4 gene. This protein is involved in the negative regulation of endothelial cell proliferation, the chemotaxis of neutrophils and monocytes and the positive regulation of blood coagulation. |
| DesignNote |
Platelet factor 4 is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its heparin-binding ability causes the neutralization of heparin-like molecules on the endothelial surface of blood vessels, which leads to the inhibition of local antithrombin III activity and promotes coagulation. PF4 is a strong chemoattractant for neutrophils and fibroblasts, which indicates a potential role in inflammation and wound repair. (OMIM) |
| Display_Name |
Platelet Factor 4 |
| FULL_SYN |
Small-Inducible Cytokine B4 C-X-C Motif Chemokine 4 CXCL4 Oncostatin-A Small Inducible Cytokine Subfamily B, Member 4 Platelet Factor 4 PF4 Chemokine (C-X-C motif) Ligand 4 Platelet Factor-4 Iroplact Small Inducible Cytokine B4 |
| label |
Platelet Factor 4 |
| Legacy Concept Name |
Platelet_Factor-4 |
| OMIM_Number |
173460 |
| Preferred_Name |
Platelet Factor 4 |
| prefixIRI |
Thesaurus:C20811 |
| prefLabel |
Platelet Factor 4 |
| Semantic_Type |
Amino Acid, Peptide, or Protein |
| Swiss_Prot |
P02776 |
| UMLS_CUI |
C0032183 |
| subClassOf |