loading...| Preferred Name |
Leukoencephalopathy, Progressive Multifocal |
| Synonyms |
Progressive Multifocal Leukoencephalopathy |
| Definitions |
An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7) |
| ID |
http://purl.bioontology.org/ontology/MESH/D007968 |
| altLabel |
Progressive Multifocal Leukoencephalopathy JC Polyomavirus Encephalopathy Encephalopathies, JC Polyomavirus Encephalitis, JC Polyomavirus Progressive Multifocal Leukoencephalopathies Multifocal Leukoencephalopathy, Progressive Encephalopathy, JC Polyomavirus Leukoencephalopathies, Progressive Multifocal Multifocal Leukoencephalopathies, Progressive JC Polyomavirus Encephalitis |
| AQL |
BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH TM UR VE VI |
| cui |
C0023524 |
| DC |
1 |
| definition |
An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7) |
| DX |
19730101 |
| HN |
1973(1971) |
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000401 http://purl.bioontology.org/ontology/MESH/Q000150 http://purl.bioontology.org/ontology/MESH/Q000188 http://purl.bioontology.org/ontology/MESH/Q000517 http://purl.bioontology.org/ontology/MESH/Q000201 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000503 http://purl.bioontology.org/ontology/MESH/Q000453 http://purl.bioontology.org/ontology/MESH/Q000208 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000821 http://purl.bioontology.org/ontology/MESH/Q000382 http://purl.bioontology.org/ontology/MESH/Q000601 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000523 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000662 http://purl.bioontology.org/ontology/MESH/Q000151 http://purl.bioontology.org/ontology/MESH/Q000628 http://purl.bioontology.org/ontology/MESH/Q000196 http://purl.bioontology.org/ontology/MESH/Q000534 http://purl.bioontology.org/ontology/MESH/Q000635 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000532 http://purl.bioontology.org/ontology/MESH/Q000139 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000175 http://purl.bioontology.org/ontology/MESH/Q000000981 http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000473 http://purl.bioontology.org/ontology/MESH/Q000451 http://purl.bioontology.org/ontology/MESH/Q000209 |
| Machine permutation |
1973 |
| MDA |
19990101 |
| MMR |
20210630 |
| MN |
C10.314.450 C01.925.256.721.500 C10.228.228.245.340.500 C01.925.182.525.500 C01.925.839.550 C10.228.140.695.750 C10.228.228.399.750.500 C01.207.245.340.500 C10.228.140.430.520.750.500 C01.207.399.750.500 C10.586.250.520.750.500 |
| notation |
D007968 |
| prefLabel |
Leukoencephalopathy, Progressive Multifocal |
| TERMUI |
T023751 T368990 T368989 T368991 |
| TH |
NLM (1971) NLM (2000) ORD (2010) |
| tui |
T047 |
| subClassOf |
http://purl.bioontology.org/ontology/MESH/D018792 http://purl.bioontology.org/ontology/MESH/D012897 http://purl.bioontology.org/ontology/MESH/D003711 |