K 252a

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1382

99533-80-9

C27H21N3O5

C1382

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

FDA

An indolocarbazole-based alkaloid and staurosporine analog isolated from Nocardiopsis and Actinomadura species, with kinase inhibiting activity. K252a inhibits a wide variety of enzymes, including, but not limited to, protein kinase A (PKA), C (PKC) and G (PKG), calcium (Ca2+)/calmodulin-dependent kinase type II (CaMKII), phosphorylase kinase (PhK), tropomyosin receptor kinase (Trk; neurotrophic tyrosine receptor kinase; NTRK), myosin light-chain kinase (MLCK; MYLK), mixed-lineage protein kinase 3 (MLK3), receptor-type tyrosine-protein kinase FLT3 (CD135; fms-like tyrosine kinase 3; fetal liver kinase-2; FLK2) and actin-regulating kinase PRK1 (PAK1). Inhibition of these kinases prevents the activation of signaling pathways in which these kinases play a key role.

IV7H45AM5B

K252A

SF 2370

K-252a

K 252a

Antibiotic SF 2370

9,1-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9-alpha,10-beta,12-alpha)-

Protein Kinase Inhibitor K252a

Antibiotic K 252A

K 252a

K_252a

K 252a

Thesaurus:C1382

K 252a

Pharmacologic Substance

Organic Chemical

C0124355

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1404