loading...| Preferred Name |
Rigosertib |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C152216 |
| CAS_Registry |
592542-59-1 |
| code |
C152216 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 |
| Contributing_Source |
CTRP GDC FDA |
| DEFINITION |
A synthetic benzyl styryl sulfone analogue and Ras mimetic, with potential antineoplastic activity. Upon administration, rigosertib targets and binds to Ras-binding domain (RBD) found in many Ras effector proteins, including Raf kinase and phosphatidylinositol 3-kinase (PI3K). This prevents Ras from binding to its targets and inhibits Ras-mediated signaling pathways, including Ras/Raf/Erk, Ras/CRAF/polo-like kinase1 (Plk1), and Ras/ PI3K/Akt signaling pathways. This induces cell cycle arrest and apoptosis and inhibits proliferation in a variety of susceptible tumor cells. |
| Display_Name |
Rigosertib |
| FDA_UNII_Code |
67DOW7F9GL |
| FULL_SYN |
Glycine, N-(2-methoxy-5-((((1E)-2-(2,4,6-trimethoxyphenyl)ethenyl)sulfonyl) methyl)phenyl)- ON 01910 RIGOSERTIB N-(2-Methoxy-5-((((1E)-2-(2,4,6-trimethoxyphenyl)ethenyl)sulfonyl)methyl) phenyl)glycine Rigosertib |
| Has_Target | |
| Is_Value_For_GDC_Property | |
| label |
Rigosertib |
| Maps_To |
Rigosertib |
| NCI_META_CUI |
CL553420 |
| Preferred_Name |
Rigosertib |
| prefixIRI |
Thesaurus:C152216 |
| prefLabel |
Rigosertib |
| Semantic_Type |
Pharmacologic Substance |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.obolibrary.org/obo/CHEBI_145417 | Chemical Entities of Biological Interest Ontology / 生物相关的化学实体本体 | LOOM |