loading...| Preferred Name |
Ionomycin |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C596 |
| CAS_Registry |
56092-81-0 |
| CHEBI_ID |
CHEBI:63954 |
| code |
C596 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923 |
| Contributing_Source |
GDC FDA |
| DEFINITION |
A polyether antibiotic isolated from Streptomyces conglobatus sp. nov. Trejo with antineoplastic activity. Ionomycin is a calcium ionophore that increases intracellular Ca++ levels, possibly relating to endonuclease activation of lymphocytes and decreased ratio of Bcl-2 to Bax and ultimately apoptosis. In addition, this agent is used to investigate the role of intracellular calcium in cellular processes. (NCI) |
| FDA_UNII_Code |
54V905V6AT |
| FULL_SYN |
ionomycin IONOMYCIN Ionomycin |
| Is_Value_For_GDC_Property | |
| label |
Ionomycin |
| Legacy Concept Name |
Ionomycin |
| Maps_To |
Ionomycin |
| NCI_Drug_Dictionary_ID |
43046 |
| PDQ_Closed_Trial_Search_ID |
43046 |
| PDQ_Open_Trial_Search_ID |
43046 |
| Preferred_Name |
Ionomycin |
| prefixIRI |
Thesaurus:C596 |
| prefLabel |
Ionomycin |
| Semantic_Type |
Pharmacologic Substance Antibiotic |
| UMLS_CUI |
C0022020 |
| subClassOf |