Preferred Name

Golvatinib

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82363

CAS_Registry

928037-13-2

Chemical_Formula

C33H37F2N7O4

code

C82363

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

GDC

FDA

DEFINITION

An orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinases with potential antineoplastic activity. c-Met/VEGFR kinase inhibitor E7050 binds to and inhibits the activities of both c-Met and VEGFR-2, which may inhibit tumor cell growth and survival of tumor cells that overexpress these receptor tyrosine kinases. c-Met and VEGFR-2 are upregulated in a variety of tumor cell types and play important roles in tumor cell growth, migration and angiogenesis.

Display_Name

Golvatinib

FDA_UNII_Code

516Z3YP58E

FULL_SYN

E7050

1,1-cyclopropanedicarboxamide, N-(2-fluoro-4-((2-(((4-(4-methyl-1-piperazinyl)-1-piperidinyl)carbonyl)amino)-4-pyridinyl)oxy)phenyl)-N'-(4-fluorophenyl)-

Golvatinib

GOLVATINIB

c-Met/VEGFR-2 Kinase Inhibitor E7050

Has_Target

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18186

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28496

Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909

label

Golvatinib

Legacy Concept Name

c-Met_VEGFR_Kinase_Inhibitor_E7050

Maps_To

Golvatinib

NCI_Drug_Dictionary_ID

640626

PDQ_Closed_Trial_Search_ID

640626

PDQ_Open_Trial_Search_ID

640626

Preferred_Name

Golvatinib

prefixIRI

Thesaurus:C82363

prefLabel

Golvatinib

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C3642430

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1404

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C129825

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http://purl.obolibrary.org/obo/CHEBI_177746 Chemical Entities of Biological Interest Ontology / 生物相关的化学实体本体 LOOM