| Preferred Name |
Golvatinib |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82363 |
| CAS_Registry |
928037-13-2 |
| Chemical_Formula |
C33H37F2N7O4 |
| code |
C82363 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 |
| Contributing_Source |
CTRP GDC FDA |
| DEFINITION |
An orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinases with potential antineoplastic activity. c-Met/VEGFR kinase inhibitor E7050 binds to and inhibits the activities of both c-Met and VEGFR-2, which may inhibit tumor cell growth and survival of tumor cells that overexpress these receptor tyrosine kinases. c-Met and VEGFR-2 are upregulated in a variety of tumor cell types and play important roles in tumor cell growth, migration and angiogenesis. |
| Display_Name |
Golvatinib |
| FDA_UNII_Code |
516Z3YP58E |
| FULL_SYN |
E7050 1,1-cyclopropanedicarboxamide, N-(2-fluoro-4-((2-(((4-(4-methyl-1-piperazinyl)-1-piperidinyl)carbonyl)amino)-4-pyridinyl)oxy)phenyl)-N'-(4-fluorophenyl)- Golvatinib GOLVATINIB c-Met/VEGFR-2 Kinase Inhibitor E7050 |
| Has_Target | |
| Is_Value_For_GDC_Property | |
| label |
Golvatinib |
| Legacy Concept Name |
c-Met_VEGFR_Kinase_Inhibitor_E7050 |
| Maps_To |
Golvatinib |
| NCI_Drug_Dictionary_ID |
640626 |
| PDQ_Closed_Trial_Search_ID |
640626 |
| PDQ_Open_Trial_Search_ID |
640626 |
| Preferred_Name |
Golvatinib |
| prefixIRI |
Thesaurus:C82363 |
| prefLabel |
Golvatinib |
| Semantic_Type |
Pharmacologic Substance |
| UMLS_CUI |
C3642430 |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.obolibrary.org/obo/CHEBI_177746 | Chemical Entities of Biological Interest Ontology / 生物相关的化学实体本体 | LOOM |