Insulin-Like Growth Factor-Binding Protein 6

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17587

C17587

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142800

CTRP

Insulin-like growth factor-binding protein 6 (240 aa, ~25 kDa) is encoded by the human IGFBP6 gene. This protein plays a role in insulin-like growth factor binding.

IGFBP6 contains a thyroglobulin type-I domain, belongs to the IGFBP family, and may function as an autocrine growth inhibitor. IGFBPs display strong sequence homologies. IGFBPs contain three distinct domains. N-terminal domain 1 and C-terminal domain 3 contain invariant cysteine residues and are the IGF binding domains. Domain 2 generally lacks sequence identity among the IGFBPs. Domain 3 is homologous to the thyroglobulin type I repeat. IGF-I and IGF-II circulate in plasma tightly bound to IGFBPs. IGFs, IGFRs, and IGFBPs regulate cell proliferation and apoptosis and the primary effect of IGFBPs appears to be modulation of IGF activity and control of IGF-mediated cell growth and metabolism. Secreted IGF-binding proteins prolong the half-life of IGFs (somatomedins) and either inhibit or stimulate the growth promoting effects of IGFs by altering the interaction of IGFs with cell surface receptors. (from OMIM 146735, SWISS-PROT P24592 and NCI)

Insulin-Like Growth Factor-Binding Protein 6

Insulin-Like Growth Factor-Binding Protein 6

IBP-6

IGF-Binding Protein 6

Insulin-Like Growth Factor Binding Protein 6

IGF Binding Protein 6

IGFBP6

IGFBP-6

Insulin-Like Growth Factor-Binding Protein 6

Insulin-Like_Growth_Factor-Binding_Protein-6

146735

Insulin-Like Growth Factor-Binding Protein 6

Thesaurus:C17587

Insulin-Like Growth Factor-Binding Protein 6

Amino Acid, Peptide, or Protein

P24592

C0169975

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17332