loading...| Preferred Name |
Interleukin-10 |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20512 |
| ALT_DEFINITION |
One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. IL-10 is made by activated macrophages and by some T lymphocytes. It reduces inflammation by blocking production of cytokines by immune cells. IL-10 also increases antibody production by plasma cells and helps them live longer. IL-10 made in the laboratory is used as a biological response modifier to boost the immune system. It is a type of cytokine. |
| code |
C20512 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 |
| Contributing_Source |
CTRP |
| DEFINITION |
Interleukin-10 (178 aa, ~21 kDa) is encoded by the human IL10 gene. This protein plays a role in the negative regulation of cytokine expression. |
| DesignNote |
Interleukin-10 down-regulates expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. |
| Display_Name |
Interleukin-10 |
| FULL_SYN |
IL-10 Interleukin-10 CSIF T-Cell Growth Inhibitory Factor Cytokine Synthesis Inhibitory Factor TGIF IL10 Interleukin 10 interleukin-10 |
| label |
Interleukin-10 |
| Legacy Concept Name |
Interleukin-10 |
| OMIM_Number |
124092 |
| Preferred_Name |
Interleukin-10 |
| prefixIRI |
Thesaurus:C20512 |
| prefLabel |
Interleukin-10 |
| Semantic_Type |
Immunologic Factor Amino Acid, Peptide, or Protein |
| Swiss_Prot |
P22301 |
| UMLS_CUI |
C1699802 |
| subClassOf |