loading...| Preferred Name |
Insulin Receptor Substrate 2 |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28475 |
| code |
C28475 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 |
| Contributing_Source |
CTRP |
| DEFINITION |
Insulin receptor substrate 2 (1338 aa, ~137 kDa) is encoded by the human IRS2 gene. This protein is involved in insulin-dependent signal transduction. |
| DesignNote |
Tyrosine-phosphorylated IRS2 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS2 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin-4 receptor (IL4R) -associated kinase in response to IL4 treatment. (LocusLink) |
| Display_Name |
Insulin Receptor Substrate 2 |
| FULL_SYN |
IRS2 Insulin Receptor Substrate 2 IRS-2 |
| label |
Insulin Receptor Substrate 2 |
| Legacy Concept Name |
Insulin_Receptor_Substrate-2 |
| OMIM_Number |
600797 |
| Preferred_Name |
Insulin Receptor Substrate 2 |
| prefixIRI |
Thesaurus:C28475 |
| prefLabel |
Insulin Receptor Substrate 2 |
| Semantic_Type |
Amino Acid, Peptide, or Protein |
| Swiss_Prot |
Q9Y4H2 |
| UMLS_CUI |
C0381451 |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.bioontology.org/ontology/OMIM/600797 | Online Mendelian Inheritance in Man / 在线人类孟德尔遗传数据库 | LOOM | |
| http://purl.obolibrary.org/obo/PR_000009108 | Protein Ontology / 蛋白质本体 | LOOM |