loading...| Preferred Name |
Transthyretin |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C79964 |
| code |
C79964 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 |
| Contributing_Source |
CTRP |
| DEFINITION |
Transthyretin (147 aa, ~16 kDa) is encoded by the human TTR gene. This protein is involved in both the binding and transport of retinol and thyroxine. |
| DesignNote |
Transthyretin is a homotetramer with two thyroxine binding sites. Less than 1% of plasma transthyretin is involved in thyroxine transport, while 40% is in a tight protein-protein complex with the plasma retinol-binding protein (RBP). The formation of the complex with RBP stabilizes the binding of retinol to RBP and decreases the glomerular filtration and renal catabolism of the RBP molecule. (UniProt) |
| Display_Name |
Transthyretin |
| FULL_SYN |
Prealbumin Thyroxine-Binding Prealbumin TTR Transthyretin ATTR TBPA |
| label |
Transthyretin |
| Legacy Concept Name |
Transthyretin |
| NCI_META_CUI |
CL1374644 |
| OMIM_Number |
176300 |
| Preferred_Name |
Transthyretin |
| prefixIRI |
Thesaurus:C79964 |
| prefLabel |
Transthyretin |
| Semantic_Type |
Amino Acid, Peptide, or Protein |
| Swiss_Prot |
P02766 |
| subClassOf |