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loading...| Preferred Name |
Presenilin-1 |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C95117 |
| code |
C95117 |
| DEFINITION |
Presenilin-1 (467 aa, ~53 kDa) is encoded by the human PSEN1 gene. This protein plays a role in the mediation of proteolysis. |
| DesignNote |
Presenilin-1 is autocatalytically processed to an amino terminal fragment (NTF) and a carboxyl terminal fragment (CTF). The NTF and CTF are maintained as a disulfide-linked heterodimer. This cleavage is required for gamma secretase activity. |
| FULL_SYN |
Presenilin-1 Presenilin 1 PS-1 PSEN1 EC 3.4.23.- Protein S182 |
| label |
Presenilin-1 |
| OMIM_Number |
104311 |
| Preferred_Name |
Presenilin-1 |
| prefixIRI |
Thesaurus:C95117 |
| prefLabel |
Presenilin-1 |
| Semantic_Type |
Enzyme Amino Acid, Peptide, or Protein |
| Swiss_Prot |
P49768 |
| UMLS_CUI |
C1311407 |
| subClassOf |
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