loading...| Preferred Name |
Interleukin-8 |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20473 |
| code |
C20473 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 |
| Contributing_Source |
CTRP |
| DEFINITION |
Interleukin-8 (99 aa, ~11 kDa) is encoded by the human CXCL8 gene. This protein is involved in chemotaxis and neutrophil activation. |
| DesignNote |
Interleukin-8 is cleaved into the following seven chains: MDNCF-a (GCP/IL-8 protein IV, IL8/NAP1 form I), Interleukin-8 ((Ala-IL-8)77, GCP/IL-8 protein II, IL-8(1-77), IL8/NAP1 form II, MDNCF-b), IL-8(5-77), IL-8(6-77) ((Ser-IL-8)72, GCP/IL-8 protein I, IL8/NAP1 form III, lymphocyte-derived neutrophil-activating factor, LYNAP, MDNCF-c, neutrophil-activating factor, NAF), IL-8(7-77) (GCP/IL-8 protein V, IL8/NAP1 form IV), IL-8(8-77) (GCP/IL-8 protein VI, IL8/NAP1 form V), and IL-8(9-77) (GCP/IL-8 protein III; IL8/NAP1 form VI). (UniProt) |
| Display_Name |
Interleukin-8 |
| FULL_SYN |
Neutrophil Activation Peptide Monocyte-Derived Neutrophil-Activating Peptide Protein 3-10C Monocyte-Derived Neutrophil Chemotactic Factor MDNCF Macrophage-Derived Chemotactic Factor Lung Giant Cell Carcinoma-Derived Chemotactic Protein NAP-1 MONAP IL-8 Leukocyte Adhesion Inhibitor Lymphocyte Derived Neutrophil Activating Peptide Beta-Thromboglobulin-Like Protein Granulocyte Chemotactic Peptide Interleukin 8 Granulocyte Chemotactic Protein 1 Beta Endothelial Cell-Derived Neutrophil Activating Peptide C-X-C Motif Chemokine 8 Anionic Neutrophil Activating Peptide Alveolar Macrophage Chemotactic Factor I T-Cell Chemotactic Factor Interleukin 8 Neutrophil-Activating Protein 1 CXCL8 Neutrophil Chemotactic Factor Neutrophil-Activating Peptide 1 IL8 Neutrophil Activation Factor GCP-1 Anionic Neutrophil-Activating Peptide GCP-IL-8 Interleukin-8 |
| label |
Interleukin-8 |
| Legacy Concept Name |
Interleukin-8 |
| OMIM_Number |
146930 |
| Preferred_Name |
Interleukin-8 |
| prefixIRI |
Thesaurus:C20473 |
| prefLabel |
Interleukin-8 |
| Semantic_Type |
Immunologic Factor Amino Acid, Peptide, or Protein |
| Swiss_Prot |
P10145 |
| UMLS_CUI |
C1698756 |
| subClassOf |