Preferred Name

Interleukin-8

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20473

code

C20473

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142800

Contributing_Source

CTRP

DEFINITION

Interleukin-8 (99 aa, ~11 kDa) is encoded by the human CXCL8 gene. This protein is involved in chemotaxis and neutrophil activation.

DesignNote

Interleukin-8 is cleaved into the following seven chains: MDNCF-a (GCP/IL-8 protein IV, IL8/NAP1 form I), Interleukin-8 ((Ala-IL-8)77, GCP/IL-8 protein II, IL-8(1-77), IL8/NAP1 form II, MDNCF-b), IL-8(5-77), IL-8(6-77) ((Ser-IL-8)72, GCP/IL-8 protein I, IL8/NAP1 form III, lymphocyte-derived neutrophil-activating factor, LYNAP, MDNCF-c, neutrophil-activating factor, NAF), IL-8(7-77) (GCP/IL-8 protein V, IL8/NAP1 form IV), IL-8(8-77) (GCP/IL-8 protein VI, IL8/NAP1 form V), and IL-8(9-77) (GCP/IL-8 protein III; IL8/NAP1 form VI). (UniProt)

Display_Name

Interleukin-8

FULL_SYN

Neutrophil Activation Peptide

Monocyte-Derived Neutrophil-Activating Peptide

Protein 3-10C

Monocyte-Derived Neutrophil Chemotactic Factor

MDNCF

Macrophage-Derived Chemotactic Factor

Lung Giant Cell Carcinoma-Derived Chemotactic Protein

NAP-1

MONAP

IL-8

Leukocyte Adhesion Inhibitor

Lymphocyte Derived Neutrophil Activating Peptide

Beta-Thromboglobulin-Like Protein

Granulocyte Chemotactic Peptide Interleukin 8

Granulocyte Chemotactic Protein 1

Beta Endothelial Cell-Derived Neutrophil Activating Peptide

C-X-C Motif Chemokine 8

Anionic Neutrophil Activating Peptide

Alveolar Macrophage Chemotactic Factor I

T-Cell Chemotactic Factor

Interleukin 8

Neutrophil-Activating Protein 1

CXCL8

Neutrophil Chemotactic Factor

Neutrophil-Activating Peptide 1

IL8

Neutrophil Activation Factor

GCP-1

Anionic Neutrophil-Activating Peptide

GCP-IL-8

Interleukin-8

label

Interleukin-8

Legacy Concept Name

Interleukin-8

OMIM_Number

146930

Preferred_Name

Interleukin-8

prefixIRI

Thesaurus:C20473

prefLabel

Interleukin-8

Semantic_Type

Immunologic Factor

Amino Acid, Peptide, or Protein

Swiss_Prot

P10145

UMLS_CUI

C1698756

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20497

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20467

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