loading...| Preferred Name |
Retinal neovascularization |
| Synonyms |
Retinal neovascularisation |
| Definitions |
In wound repair, neovascularization (NV) involves the sprouting of new vessels from pre-existent vessels to repair or replace damaged vessels. In the retina, NV is a response to ischemia. The NV adheres to the inner surface of the retina and outer surface of the vitreous. NV are deficient in tight junctions and hence leak plasma into surrounding tissue including the vitreous. Plasma causes the vitreous gel to degenerate, contract, and eventually collapse which pulls on the retina. Since retinal NV is adherent to both retina and vitreous, as the vitreous contracts the NV may be sheared resulting in vitreous hemorrhage or the NV may remain intact and pull the retina with the vitreous resulting in retinal elevation referred to as traction retinal detachment. When traction retinal detachment involves the macula, which is responsible for reading and driving vision, severe visual loss occurs. |
| ID |
http://purl.obolibrary.org/obo/HP_0030666 |
| comment |
When traction retinal detachment involves the macula, which is responsible for reading and driving vision, severe visual loss occurs. |
| creator | |
| database_cross_reference |
MSH:D015861 UMLS:C0035320 SNOMEDCT_US:61267008 |
| definition |
In wound repair, neovascularization (NV) involves the sprouting of new vessels from pre-existent vessels to repair or replace damaged vessels. In the retina, NV is a response to ischemia. The NV adheres to the inner surface of the retina and outer surface of the vitreous. NV are deficient in tight junctions and hence leak plasma into surrounding tissue including the vitreous. Plasma causes the vitreous gel to degenerate, contract, and eventually collapse which pulls on the retina. Since retinal NV is adherent to both retina and vitreous, as the vitreous contracts the NV may be sheared resulting in vitreous hemorrhage or the NV may remain intact and pull the retina with the vitreous resulting in retinal elevation referred to as traction retinal detachment. |
| has_exact_synonym |
Retinal neovascularisation |
| has_obo_namespace |
human_phenotype |
| id |
HP:0030666 |
| label |
Retinal neovascularization |
| notation |
HP:0030666 |
| prefLabel |
Retinal neovascularization |
| treeView | |
| subClassOf |