loading...| Preferred Name |
Fentanyl |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C494 |
| CAS_Registry |
437-38-7 |
| CHEBI_ID |
CHEBI:119915 |
| Chemical_Formula |
C22H28N2O |
| code |
C494 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 |
| Contributing_Source |
CTRP FDA |
| DEFINITION |
A synthetic, lipophilic phenylpiperidine opioid agonist with analgesic and anesthetic properties. Fentanyl selectively binds to and activates the mu-receptor in the central nervous system (CNS) thereby mimicking the effects of endogenous opiates. Activation of the mu-subtype opioid receptor stimulates the exchange of GTP for GDP on the G-protein complex and subsequently inhibits adenylate cyclase. This causes a decrease in intracellular cAMP which inhibits cAMP-mediated calcium influx into the cell via the calcium channels and thereby results in hyperpolarization and reduced neuronal excitability. |
| Display_Name |
Fentanyl |
| FDA_UNII_Code |
UF599785JZ |
| FULL_SYN |
FENTANYL Fentanyl Duragesic N-(1-phenethylpiperidin-4-yl)-N-phenylpropionamide Abstral |
| Has_Salt_Form | |
| label |
Fentanyl |
| Legacy Concept Name |
Fentanyl |
| Preferred_Name |
Fentanyl |
| prefixIRI |
Thesaurus:C494 |
| prefLabel |
Fentanyl |
| Semantic_Type |
Pharmacologic Substance Organic Chemical |
| UMLS_CUI |
C0591423 |
| subClassOf |