SHC-Transforming Protein 3

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29961

C29961

SHC-transforming protein 3 (594 aa, ~64 kDa) is encoded by the human SHC3 gene. This protein is involved in the mediation of growth factor receptor-dependent signaling pathways in neurons.

SHC3 appears involved in signaling from BDNF/TRKB to the RAS/MAPK pathway. BDNF induces tyrosine phosphorylation of SHC3 and binding to TRKB. Activated EGFR also interacts with and tyrosine-phosphorylates SHC3, inducing an association with GRB2. SHC3 and SCK mediate EGF signaling, but SHC3 has a higher affinity for TRKA and TRKB.

Neuronal SHC

Neuronal SHC-Like Protein

SH2 Domain Protein C3

SHC-Transforming Protein 3

SHC3

SHCC

SHC Protein C

SHC Transforming Protein 3

NSHC

Src Homology 2 Domain-Containing-Transforming Protein C3

Protein Rai

Neuronal Shc

SRC Homology 2 Domain Containing Transforming Protein C3

SHC-Transforming Protein C

N-Shc

Src Homology 2 Domain-Containing Transforming Protein C3

SHC-Transforming Protein 3

Neuronal-SHC_Protein

605263

SHC-Transforming Protein 3

Thesaurus:C29961

SHC-Transforming Protein 3

Amino Acid, Peptide, or Protein

Q92529

C1312067

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26231