Preferred Name

Deslorelin

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38709

Accepted_Therapeutic_Use_For

Central precocious puberty

ALT_DEFINITION

A substance being studied in the treatment of cancer as a way to block sex hormones made by the ovaries or testicles. It is a type of gonadotropin-releasing hormone analog.

CAS_Registry

57773-65-6

Chemical_Formula

C64H83N17O12

code

C38709

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

GDC

FDA

DEFINITION

A synthetic nonapeptide analogue of the natural gonadotrophin releasing hormone (GnRH) with potential antineoplastic activity. Deslorelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Continuous, prolonged administration of goserelin in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. (NCI04)

Display_Name

Deslorelin

FDA_UNII_Code

TKG3I66TVE

FULL_SYN

Deslorelin

DESLORELIN

6-D-Tryptophan-9-(N-ethyl-L-prolinamide)-1-9-luteinizing Hormone-releasing Factor (Swine)

Ovuplant

deslorelin

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82600

Has_Target

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38910

Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909

label

Deslorelin

Legacy Concept Name

Deslorelin

Maps_To

Deslorelin

NCI_Drug_Dictionary_ID

357620

PDQ_Closed_Trial_Search_ID

357620

PDQ_Open_Trial_Search_ID

357620

Preferred_Name

Deslorelin

prefixIRI

Thesaurus:C38709

prefLabel

Deslorelin

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0083220

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1910

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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_177570 Chemical Entities of Biological Interest Ontology / 生物相关的化学实体本体 LOOM
http://purl.obolibrary.org/obo/CHEBI_177570 The Drug Ontology / 药物本体 LOOM
http://purl.bioontology.org/ontology/MESH/C066438 Medical Subject Headings / 医学主题词表 LOOM