loading...| Preferred Name |
Methylprednisolone Acetate |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48003 |
| CAS_Registry |
53-36-1 |
| CHEBI_ID |
CHEBI:6889 |
| Chemical_Formula |
C24H32O6 |
| code |
C48003 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 |
| Contributing_Source |
GDC FDA |
| DEFINITION |
The acetate salt of a synthetic glucocorticoid receptor agonist with immunosuppressive and antiinflammatory effects. Methylprednisolone acetate is converted into active prednisolone in the body, which activates glucocorticoid receptor mediated gene expression. This includes inducing synthesis of anti-inflammatory protein IkappaB-alpha and inhibiting synthesis of nuclear factor kappaB (NF-kappaB). As a result, proinflammatory cytokine production such as IL-1, IL-2 and IL-6 is down-regulated and cytotoxic T-lymphocyte activation is inhibited. Therefore, an overall reduction in chronic inflammation and autoimmune reactions may be achieved. |
| FDA_UNII_Code |
43502P7F0P |
| FULL_SYN |
D-Med ReadySharp MethylPrednisolone 80 11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-Acetate Depo-Medrone Depo-Medrol Methylprednisolone Acetate Depo-Medrate Methylprednisolone acetate METHYLPREDNISOLONE ACETATE |
| Is_Value_For_GDC_Property | |
| label |
Methylprednisolone Acetate |
| Legacy Concept Name |
Methylprednisolone_Acetate |
| Maps_To |
Methylprednisolone Acetate |
| NCI_Drug_Dictionary_ID |
41528 |
| NSC Number |
48985 |
| PDQ_Closed_Trial_Search_ID |
41528 |
| PDQ_Open_Trial_Search_ID |
41528 |
| Preferred_Name |
Methylprednisolone Acetate |
| prefixIRI |
Thesaurus:C48003 |
| prefLabel |
Methylprednisolone Acetate |
| Semantic_Type |
Pharmacologic Substance |
| UMLS_CUI |
C0600901 |
| subClassOf |