loading...| Preferred Name |
Indomethacin |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C576 |
| Accepted_Therapeutic_Use_For |
Dysmennorhea; Inflammatory disorders; Pain |
| ALT_DEFINITION |
A drug that reduces pain, fever, swelling, and redness. It is also being used to reduce tumor-induced suppression of the immune system and to increase the effectiveness of anticancer drugs. It is a type of nonsteroidal anti-inflammatory drug (NSAID). |
| CAS_Registry |
53-86-1 |
| CHEBI_ID |
CHEBI:49662 |
| Chemical_Formula |
C19H16ClNO4 |
| code |
C576 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 |
| Contributing_Source |
CTRP GDC FDA |
| DEFINITION |
A synthetic nonsteroidal indole derivative with anti-inflammatory activity and chemopreventive properties. As a nonsteroidal anti-inflammatory drug (NSAID), indomethacin inhibits the enzyme cyclooxygenase, thereby preventing cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines. This agent also may inhibit the expression of multidrug-resistant protein type 1, resulting in increased efficacies of some antineoplastic agents in treating multi-drug resistant tumors. In addition, indomethacin activates phosphatases that inhibit the migration and proliferation of cancer cells and downregulates survivin, which may result in tumor cell apoptosis. (NCI04) |
| Display_Name |
Indomethacin |
| FDA_UNII_Code |
XXE1CET956 |
| FULL_SYN |
INDOMETHACIN Indocin Indometacin 1-(4-chlorobenzoyl)-5-methoxy- 2-methyl-1-H-indole-3-acetic acid indomethacin Indomethacin |
| Has_Salt_Form | |
| Has_Target | |
| Is_Value_For_GDC_Property | |
| label |
Indomethacin |
| Legacy Concept Name |
Indomethacin |
| Maps_To |
Indomethacin |
| NCI_Drug_Dictionary_ID |
39489 |
| NSC Number |
77541 |
| PDQ_Closed_Trial_Search_ID |
39489 |
| PDQ_Open_Trial_Search_ID |
39489 |
| Preferred_Name |
Indomethacin |
| prefixIRI |
Thesaurus:C576 |
| prefLabel |
Indomethacin |
| Semantic_Type |
Pharmacologic Substance Organic Chemical |
| UMLS_CUI |
C0021246 |
| subClassOf |