loading...| Preferred Name |
Tesevatinib |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62496 |
| CAS_Registry |
781613-23-8 |
| code |
C62496 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 |
| Contributing_Source |
CTRP GDC FDA |
| DEFINITION |
An orally bioavailable small-molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Tesevatinib binds to and inhibits several tyrosine receptor kinases that play major roles in tumor cell proliferation and tumor vascularization, including epidermal growth factor receptor (EGFR; ERBB1), epidermal growth factor receptor 2 (HER2; ERBB2), vascular endothelial growth factor receptor (VEGFR), and ephrin B4 (EphB4). This may result in the inhibition of tumor growth and angiogenesis, and tumor regression. |
| Display_Name |
Tesevatinib |
| FDA_UNII_Code |
F6XM2TN5A1 |
| FULL_SYN |
XL647 TESEVATINIB Tesevatinib EXEL 7647 KD 019 4-Quinazolinamine, N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-(((3aalpha,5beta,6aalpha)-octahydro-2-methylcyclopenta(c)pyrrol-5-yl)methoxy)- KD019 |
| Has_Target |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17319 |
| Is_Value_For_GDC_Property | |
| label |
Tesevatinib |
| Legacy Concept Name |
XL647 |
| Maps_To |
Tesevatinib |
| NCI_Drug_Dictionary_ID |
386183 |
| PDQ_Closed_Trial_Search_ID |
386183 |
| PDQ_Open_Trial_Search_ID |
386183 |
| Preferred_Name |
Tesevatinib |
| prefixIRI |
Thesaurus:C62496 |
| prefLabel |
Tesevatinib |
| PubMedID_Primary_Reference |
22011666 |
| Semantic_Type |
Pharmacologic Substance |
| UMLS_CUI |
C1541356 |
| subClassOf |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1742 |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.obolibrary.org/obo/CHEBI_167674 | Chemical Entities of Biological Interest Ontology / 生物相关的化学实体本体 | LOOM |