loading...| Preferred Name |
non-neural ectoderm |
| Synonyms |
epithelial ectoderm surface ectoderm ventral ectoderm epidermal ectoderm non neural ectoderm |
| Definitions |
Gene notes: One of the first genes to be expressed in nonneural ectoderm in amphioxus is BMP2/4 (Panopoulou et al. 1998). BMP2/4 homologues appear to have a very ancient role in distinguishing neural from nonneural ectoderm; in Drosophila as well as in amphioxus and vertebrates, BMP2/4 homologues are expressed in nonneural ectoderm and function in distinguishing neural from nonneural ectoderm (Francois & Bier, 1995 ; Sasai et al. 1995 ; Wilson & Hemmati-Brivanlou, 1995; Panopoulou et al. 1998). A change in level of BMP2/4 from very high in nonneural ectoderm to low in neural ectoderm appears to be a key factor in development of neural crest (Baker & Bronner-Fraser,1997a,1997b;Erickson&Reedy,1998;Marchantet al.1998 ;Selleck et al. 1998). |
| ID |
http://purl.obolibrary.org/obo/UBERON_0005497 |
| comment |
Gene notes: One of the first genes to be expressed in nonneural ectoderm in amphioxus is BMP2/4 (Panopoulou et al. 1998). BMP2/4 homologues appear to have a very ancient role in distinguishing neural from nonneural ectoderm; in Drosophila as well as in amphioxus and vertebrates, BMP2/4 homologues are expressed in nonneural ectoderm and function in distinguishing neural from nonneural ectoderm (Francois & Bier, 1995 ; Sasai et al. 1995 ; Wilson & Hemmati-Brivanlou, 1995; Panopoulou et al. 1998). A change in level of BMP2/4 from very high in nonneural ectoderm to low in neural ectoderm appears to be a key factor in development of neural crest (Baker & Bronner-Fraser,1997a,1997b;Erickson&Reedy,1998;Marchantet al.1998 ;Selleck et al. 1998). |
| database_cross_reference |
EFO:0003643 VHOG:0001372 ZFA:0001178 EMAPA:16074 XAO:0004091 RETIRED_EHDAA2:0001273 EHDAA:257 TAO:0001178 |
| editor note |
todo - epidermis? todo - track down EHDAA2 class in new release |
| has_exact_synonym |
non neural ectoderm |
| has_narrow_synonym |
epithelial ectoderm epidermal ectoderm |
| has_obo_namespace |
uberon |
| has_related_synonym |
surface ectoderm ventral ectoderm |
| id |
UBERON:0005497 |
| in_subset | |
| label |
non-neural ectoderm |
| notation |
UBERON:0005497 |
| prefLabel |
non-neural ectoderm |
| RO_0002171 | |
| UBPROP_0000003 |
In the early gastrula of vertebrates, factors from the organizer (e.g. noggin, chordin, and follistatin in Xenopus) antagonize the epidermalizing factor bone morphogenetic protein 4 (BMP4), thus dividing the epiblast into neuroectoderm. In Drosophila, decapentaplegic, the homologue of BMP4, interacts similarly with the protein short gastrulation, the homologue of chordin. Thus, a comparable molecular mechanism for distinguishing non-neural ectoderm from neural ectoderm was probably present in the common ancestor of all bilaterally symmetrical animals.[well established][VHOG] |
| UBPROP_0000011 |
After gastrulation, neural crest cells are specified at the border of the neural plate and the non-neural ectoderm. |
| subClassOf |