loading...| Preferred Name |
receptor-type tyrosine-protein phosphatase C |
| Synonyms |
L-CA |
| Definitions |
是人PTPRC基因或其1：1直系同源物的翻译产物的蛋白质。它由一个胞外结构域，一个单跨膜片段和两个串联的胞质内蛋白酪氨酸磷酸酶结构域组成。含有1至3个纤连蛋白III型结构域（Pfam：PF00041）的拷贝，随后是两个蛋白酪氨酸磷酸酶（Pfam：PF00102）结构域的拷贝。受体型酪氨酸蛋白磷酸酶C（CD45）通过与T和B细胞上的受体分子特异性结合来调节信号转导和淋巴细胞活化。CD45 (180-235 kDa)的多种亚型可由3个变量外显子4(a)、5(B)和6(C)的选择性剪接产生，编码位于分子的N端胞外区域的序列。 A protein that is a translation product of the human PTPRC gene or a 1:1 ortholog thereof. It is composed of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic protein-tyrosine phosphatase domains. Contains 1 to 3 copies of the Fibronectin type III domain (Pfam:PF00041) followed by two copies of the Protein-tyrosine phosphatase (Pfam:PF00102) domain. Receptor-type tyrosine-protein phosphatase C (CD45) regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T and B cells. Multiple isoforms of CD45 (180-235 kDa) can be generated asa result of alternative splicing of three variable exons 4(A), 5(B) and 6(C), encoding sequences at the N-terminal extracellular domain of the molecule. |
| ID |
http://purl.obolibrary.org/obo/PR_000001006 |
| has_broad_synonym |
T200 |
| label |
受体型酪氨酸蛋白磷酸酶C receptor-type tyrosine-protein phosphatase C |
| prefixIRI |
PR:000001006 |
| prefLabel |
receptor-type tyrosine-protein phosphatase C |
| textual definition |
是人PTPRC基因或其1：1直系同源物的翻译产物的蛋白质。它由一个胞外结构域，一个单跨膜片段和两个串联的胞质内蛋白酪氨酸磷酸酶结构域组成。含有1至3个纤连蛋白III型结构域（Pfam：PF00041）的拷贝，随后是两个蛋白酪氨酸磷酸酶（Pfam：PF00102）结构域的拷贝。受体型酪氨酸蛋白磷酸酶C（CD45）通过与T和B细胞上的受体分子特异性结合来调节信号转导和淋巴细胞活化。CD45 (180-235 kDa)的多种亚型可由3个变量外显子4(a)、5(B)和6(C)的选择性剪接产生，编码位于分子的N端胞外区域的序列。 A protein that is a translation product of the human PTPRC gene or a 1:1 ortholog thereof. It is composed of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic protein-tyrosine phosphatase domains. Contains 1 to 3 copies of the Fibronectin type III domain (Pfam:PF00041) followed by two copies of the Protein-tyrosine phosphatase (Pfam:PF00102) domain. Receptor-type tyrosine-protein phosphatase C (CD45) regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T and B cells. Multiple isoforms of CD45 (180-235 kDa) can be generated asa result of alternative splicing of three variable exons 4(A), 5(B) and 6(C), encoding sequences at the N-terminal extracellular domain of the molecule. |
| 引自 | |
| 有_精确的_同义词 |
L-CA leukocyte common antigen CD45 白细胞常见抗原 淋巴细胞抗原5 PTPRC lymphocyte antigen 5 ly-5 |
| subClassOf |