loading...| Preferred Name |
eosinophil |
| Synonyms |
polymorphonuclear leucocyte eosinocyte eosinophilic leucocyte polymorphonuclear leukocyte eosinophilic granulocyte eosinophilic leukocyte |
| Definitions |
Any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Eosinophils are CD9-positive, CD191-positive, and CD193-positive. Eosinophils are also CD14-negative, CD32-positive, CD44-positive, CD48-positive, CD69-positive, CD192-negative, MBP1-positive, MBP2-positive, TLR2-negative, TLR4-negative, and lineage-negative (B220, CD2, CD14, CD19, CD56, CD71, CD117, CD123, CD235a (glycophorin A), and TER119). The cytokines IL-3, IL-5, and GM-CSF are involved in their development and differentiation. Usually considered CD16-negative, CD16 is observed on eosinophilic metamyelocyte. |
| ID |
http://purl.obolibrary.org/obo/CL_0000771 |
| comment |
Eosinophils are also CD14-negative, CD32-positive, CD44-positive, CD48-positive, CD69-positive, CD192-negative, MBP1-positive, MBP2-positive, TLR2-negative, TLR4-negative, and lineage-negative (B220, CD2, CD14, CD19, CD56, CD71, CD117, CD123, CD235a (glycophorin A), and TER119). The cytokines IL-3, IL-5, and GM-CSF are involved in their development and differentiation. Usually considered CD16-negative, CD16 is observed on eosinophilic metamyelocyte. |
| database_cross_reference |
FMA:62861 CALOHA:TS-0279 BTO:0000399 MeSH:D004804 NCIt:C12532 SNOMEDCT:14793004 MESH:D004804 |
| definition |
Any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Eosinophils are CD9-positive, CD191-positive, and CD193-positive. |
| has_broad_synonym |
polymorphonuclear leucocyte polymorphonuclear leukocyte |
| has_exact_synonym |
eosinocyte eosinophilic leucocyte eosinophilic granulocyte eosinophilic leukocyte |
| in_subset |
http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas |
| label |
eosinophil |
| prefixIRI |
obo2:CL_0000771 |
| prefLabel |
eosinophil |
| RO_0002175 | |
| subClassOf |