loading...| Preferred Name |
gamma-secretase complex |
| Synonyms |
gamma-secretase complex (APH1A, PSEN2, PSENEN, NCSTN) PS1 complex presenilin complex PS2 complex gamma-secretase complex (APH1B, PSEN1, PSENEN, NCSTN) CD147-gamma-secretase complex (APH-1a, PS-1, PEN-2, NCT variant) gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN) gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN variant) |
| Definitions |
A protein complex that has aspartic-type endopeptidase activity and contains a presenilin catalytic subunit (either PSEN1 or PSEN2), an APH1 subunit (multiple genes and splice variants exist), nicastrin (NCT), and presenilin enhancer (aka PEN-2 or Psenen), as the core complex. Variants of the complex with different subunit compositions differ in localization and specific substrates. Additionally, variants of the complex exist that contain a additional regulatory subunit as well as the four core subunits; known regulatory subunits include gamma-secretase-activating protein (aka gSAP), TMP1 (aka TMED10), and CD147 antigen (aka basigin). Gamma-secretase cleaves type I transmembrane protein substrates, including the cell surface receptor Notch and the amyloid-beta precursor protein. |
| ID |
http://purl.obolibrary.org/obo/GO_0070765 |
| created_by |
mah |
| creation_date |
2009-06-29T01:33:19Z |
| definition |
A protein complex that has aspartic-type endopeptidase activity and contains a presenilin catalytic subunit (either PSEN1 or PSEN2), an APH1 subunit (multiple genes and splice variants exist), nicastrin (NCT), and presenilin enhancer (aka PEN-2 or Psenen), as the core complex. Variants of the complex with different subunit compositions differ in localization and specific substrates. Additionally, variants of the complex exist that contain a additional regulatory subunit as well as the four core subunits; known regulatory subunits include gamma-secretase-activating protein (aka gSAP), TMP1 (aka TMED10), and CD147 antigen (aka basigin). Gamma-secretase cleaves type I transmembrane protein substrates, including the cell surface receptor Notch and the amyloid-beta precursor protein. |
| has_exact_synonym |
presenilin complex |
| has_narrow_synonym |
gamma-secretase complex (APH1A, PSEN2, PSENEN, NCSTN) PS1 complex PS2 complex gamma-secretase complex (APH1B, PSEN1, PSENEN, NCSTN) CD147-gamma-secretase complex (APH-1a, PS-1, PEN-2, NCT variant) gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN) gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN variant) |
| has_obo_namespace |
cellular_component |
| id |
GO:0070765 |
| label |
gamma-secretase complex |
| notation |
GO:0070765 |
| prefLabel |
gamma-secretase complex |
| term tracker item | |
| treeView | |
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| There are currently no mappings for this class. | |||