loading...| Preferred Name |
astromicin |
| Synonyms |
KW-1070 4-amino-1-((aminoacetyl)methylamino)-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranosyl)-6-O-methyl-L-chiro-inositol N-[(1S,2R,3R,4S,5S,6R)-4-amino-3-({(2R,3R,6S)-3-amino-6-[(1S)-1-aminoethyl]tetrahydro-2H-pyran-2-yl}oxy)-2,5-dihydroxy-6-methoxycyclohexyl]-N-methylglycinamide KW 1070 astromicine ASTM astromycin astromicin 4-amino-1-(2-amino-N-methylacetamido)-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranosyl)-6-O-methyl-L-chiro-inositol Astromicin astromicina XK-70-1 antibiotic KW-1070 fortimicin A astromicinum XK 70-1 |
| Definitions |
An amino cyclitol glycoside that is L-chiro-inositol in which the hydroxy groups at positions 1, 4, and 6 are replaced by aminoacetyl)methylamino, amino, and methoxy groups, respectively, and in which the hydroxy group at position 3 is converted to the corresponding 2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranoside. The major component of fortimicin, obtained from Micromonospora olivasterospora. It is administered (as the sulfate salt) by intramuscular injection or intravenous infusion for the treatment of severe systemic infections due to sensitive Gram-negative organisms. |
| ID |
http://purl.obolibrary.org/obo/CHEBI_37923 |
| charge |
0 |
| database_cross_reference |
PMID:6526735 PMID:6526734 CAS:55779-06-1 PMID:2737953 Wikipedia:Astromicin KEGG:C17708 KEGG:D07470 PMID:8486289 Reaxys:3570275 Drug_Central:250 PMID:1494349 |
| definition |
An amino cyclitol glycoside that is L-chiro-inositol in which the hydroxy groups at positions 1, 4, and 6 are replaced by aminoacetyl)methylamino, amino, and methoxy groups, respectively, and in which the hydroxy group at position 3 is converted to the corresponding 2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranoside. The major component of fortimicin, obtained from Micromonospora olivasterospora. It is administered (as the sulfate salt) by intramuscular injection or intravenous infusion for the treatment of severe systemic infections due to sensitive Gram-negative organisms. |
| formula |
C17H35N5O6 |
| has role | |
| has_exact_synonym |
N-[(1S,2R,3R,4S,5S,6R)-4-amino-3-({(2R,3R,6S)-3-amino-6-[(1S)-1-aminoethyl]tetrahydro-2H-pyran-2-yl}oxy)-2,5-dihydroxy-6-methoxycyclohexyl]-N-methylglycinamide Astromicin |
| has_obo_namespace |
chebi_ontology |
| has_related_synonym |
KW-1070 4-amino-1-((aminoacetyl)methylamino)-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranosyl)-6-O-methyl-L-chiro-inositol KW 1070 astromicine ASTM astromycin astromicin 4-amino-1-(2-amino-N-methylacetamido)-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranosyl)-6-O-methyl-L-chiro-inositol astromicina XK-70-1 antibiotic KW-1070 fortimicin A astromicinum XK 70-1 |
| id |
CHEBI:37923 |
| in_subset | |
| inchi |
InChI=1S/C17H35N5O6/c1-7(19)9-5-4-8(20)17(27-9)28-15-11(21)13(24)16(26-3)12(14(15)25)22(2)10(23)6-18/h7-9,11-17,24-25H,4-6,18-21H2,1-3H3/t7-,8+,9-,11-,12-,13-,14+,15+,16+,17+/m0/s1 |
| inchikey |
BIDUPMYXGFNAEJ-APGVDKLISA-N |
| label |
astromicin |
| mass |
405.48970 |
| monoisotopicmass |
405.25873 |
| notation |
CHEBI:37923 |
| prefLabel |
astromicin |
| smiles |
[H][C@]1(CC[C@@H](N)[C@@H](O[C@@H]2[C@@H](N)[C@H](O)[C@H](OC)[C@H]([C@H]2O)N(C)C(=O)CN)O1)[C@H](C)N |
| treeView |
http://purl.obolibrary.org/obo/CHEBI_22507 http://purl.obolibrary.org/obo/CHEBI_50994 http://purl.obolibrary.org/obo/CHEBI_23824 |
| subClassOf |
http://purl.obolibrary.org/obo/CHEBI_22507 http://purl.obolibrary.org/obo/CHEBI_50994 http://purl.obolibrary.org/obo/CHEBI_23824 |