loading...| Preferred Name |
Neprilysin |
| Synonyms |
Enkephalinase |
| Definitions |
Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT. |
| ID |
http://purl.bioontology.org/ontology/MESH/D015260 |
| altLabel |
Enkephalinase Kidney-Brush-Border Neutral Proteinase CD10 Antigens Common Acute Lymphoblastic Leukemia Antigens Endopeptidase, Neutral Kidney Brush Border Neutral Proteinase Neutral Endopeptidase Thermolysin-Like Metalloendopeptidase Membrane Metallo Endopeptidase YGG-Forming Enzyme Endopeptidase-24.11 Antigens, Leukemia, Common Acute Lymphoblastic Antigen, CD10 Neutral Proteinase, Kidney-Brush-Border Endopeptidase 24.11, Neutral Neutral Endopeptidase 24.11 CALLA Antigen Membrane Metallo-Endopeptidase Enkephalinase 24.11 Enzyme, YGG-Forming YGG Forming Enzyme Carboxypeptidase, Enkephalin Dipeptidyl Metalloendopeptidase, Thermolysin-Like Dipeptidyl Carboxypeptidase, Enkephalin Endopeptidase 24.11 Thermolysin Like Metalloendopeptidase Atriopeptidase Antigens, CD10 Enkephalinase-24.11 Enkephalin Dipeptidyl Carboxypeptidase CD10 Antigen Metallo-Endopeptidase, Membrane |
| AQL |
AD AE AI AN BI BL CF CH CL CS DE DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR |
| cui |
C0025250 |
| DC |
1 |
| definition |
Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT. |
| DX |
19890101 |
| HN |
1997; was MEMBRANE METALLO-ENDOPEPTIDASE 1989-96; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGENS was COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGENS (NM) 1983-92 |
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000187 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000528 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000648 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000172 |
| Inverse of RB |
EC 3.4.24.11 |
| Machine permutation |
1997; was MEMBRANE METALLO-ENDOPEPTIDASE 1989-96; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGENS was indexed under ANTIGENS, NEOPLASM & ANTIGENS, DIFFERENTIATION 1983-92; for CALLA ANTIGEN see CALLA 1993-2002 |
| Mapped from |
http://purl.bioontology.org/ontology/MESH/C442434 http://purl.bioontology.org/ontology/MESH/C553201 http://purl.bioontology.org/ontology/MESH/C000601005 http://purl.bioontology.org/ontology/MESH/C530673 http://purl.bioontology.org/ontology/MESH/C000624573 http://purl.bioontology.org/ontology/MESH/C476216 |
| MDA |
19880518 |
| MMR |
20170524 |
| MN |
D08.811.277.656.675.374.600 D08.811.277.656.300.480.600 D23.050.285.550 D23.101.140.500 |
| notation |
D015260 |
| OL |
use NEPRILYSIN (NM) to search COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGENS 1983-92 |
| prefLabel |
Neprilysin |
| TERMUI |
T044812 T044816 T044814 T044808 T044818 T044821 T044806 T044804 T458809 T044813 T044819 T044811 T044815 T044805 T044809 T044820 T044810 T044807 |
| TH |
NLM (1993) UNK (19XX) NLM (1992) NLM (1990) NLM (1989) NLM (2003) NLM (1997) |
| tui |
T116 T126 |
| subClassOf |
http://purl.bioontology.org/ontology/MESH/D008666 |