loading...| Preferred Name |
Taurolidine |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2639 |
| Accepted_Therapeutic_Use_For |
Bronchiectasis; Catheter-Related Sepsis; Otitis Media; Peritonitis; Thoracic Empyema |
| ALT_DEFINITION |
A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called anti-infectives. |
| CAS_Registry |
19388-87-5 |
| Chemical_Formula |
C7H16N4O4S2 |
| code |
C2639 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923 |
| Contributing_Source |
GDC FDA |
| DEFINITION |
A synthetic broad-spectrum antimicrobial with antibacterial, antifungal, anticoagulant, and potential antiangiogenic activities. Taurolidine, derived from the amino acid taurine, binds to and neutralizes bacterial exotoxins and endotoxins, or lipopolysaccharides (LPS). Taurolidine binding to LPS prevents bacterial adherence to host epithelial cells, thereby prevents bacterial invasion of uninfected host cells. Although the mechanism underlying its antineoplastic activity has not been fully elucidated, it may be related to this agent's anti-adherence property. In addition, taurolidine also promotes apoptosis by inducing various apoptotic factors and suppresses the production of vascular endothelial growth factor (VEGF), a protein that plays an important role in angiogenesis. |
| FDA_UNII_Code |
8OBZ1M4V3V |
| FULL_SYN |
Taurolidine TAUROLIDINE Bis(1,1-dioxoperhydro-1,2,4-thiadiazinyl-4)-methane Taurolin taurolidine |
| Is_Value_For_GDC_Property | |
| label |
Taurolidine |
| Legacy Concept Name |
Taurolidine |
| Maps_To |
Taurolidine |
| NCI_Drug_Dictionary_ID |
38354 |
| PDQ_Closed_Trial_Search_ID |
38354 |
| PDQ_Open_Trial_Search_ID |
38354 |
| Preferred_Name |
Taurolidine |
| prefixIRI |
Thesaurus:C2639 |
| prefLabel |
Taurolidine |
| Semantic_Type |
Pharmacologic Substance |
| UMLS_CUI |
C0144567 |
| subClassOf |