loading...| Preferred Name |
Lipopolysaccharide |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101788 |
| CHEBI_ID |
CHEBI:16412 |
| code |
C101788 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 |
| Contributing_Source |
CTRP |
| DEFINITION |
An endotoxin and biologically active component of the Gram-negative bacterial cell wall that is a Toll-like receptor 4 (TLR4) agonist with potential immunostimulatory activity. Upon internalization, lipopolysaccharide (LPS) activates TLR4 which in turn activates the NFkappaB pathway, in addition to mitogen-activated protein kinases signaling pathways. This leads to the release of proinflammatory cytokines and stimulates an innate immune response against vaccine antigens. |
| Display_Name |
Lipopolysaccharide |
| FULL_SYN |
Lipopolysaccharide LPS |
| label |
Lipopolysaccharide |
| NCI_Drug_Dictionary_ID |
732862 |
| PDQ_Closed_Trial_Search_ID |
732862 |
| PDQ_Open_Trial_Search_ID |
732862 |
| Preferred_Name |
Lipopolysaccharide |
| prefixIRI |
Thesaurus:C101788 |
| prefLabel |
Lipopolysaccharide |
| Semantic_Type |
Pharmacologic Substance Organic Chemical |
| UMLS_CUI |
C0023810 |
| subClassOf |