loading...| Preferred Name |
DNA Nucleotidylexotransferase |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16509 |
| code |
C16509 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 |
| Contributing_Source |
CTRP |
| DEFINITION |
DNA nucleotidylexotransferase (509 aa, ~59 kDa) is encoded by the human DNTT gene. This protein plays a role in DNA polymerization and specifically catalyzes the insertion of nucleotides (N regions) at the V(H)-D and D-J(H) junctions of immunoglobulin genes. |
| DesignNote |
Terminal deoxynucleotidyltransferase is a unique DNA polymerase that without template direction catalyzes the addition of deoxyribonucleotides onto the 3-prime-hydroxyl end of DNA primers. The enzyme is present in immature thymocytes, some bone marrow cells, transformed pre-B and pre-T cell lines, and leukemia cells. |
| Display_Name |
DNA Nucleotidylexotransferase |
| FULL_SYN |
EC 2.7.7.31 Terminal Addition Enzyme Terminal Deoxyribonucleotidyl Transferase Terminal Deoxynucleotidyltransferase DNA Nucleotidylexotransferase TdT Deoxynucleotidyl Terminal Transferase TDT DNTT Terminal Transferase |
| label |
DNA Nucleotidylexotransferase |
| Legacy Concept Name |
Terminal_Deoxyribonucleotidyl_Transferase |
| OMIM_Number |
187410 |
| Preferred_Name |
DNA Nucleotidylexotransferase |
| prefixIRI |
Thesaurus:C16509 |
| prefLabel |
DNA Nucleotidylexotransferase |
| Semantic_Type |
Enzyme Amino Acid, Peptide, or Protein |
| Swiss_Prot |
P04053 |
| UMLS_CUI |
C0012881 |
| subClassOf |