loading...| Preferred Name |
Insulin-Like Growth Factor I |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16743 |
| code |
C16743 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 |
| Contributing_Source |
CTRP |
| DEFINITION |
Insulin-like growth factor I (195 aa, ~22 kDa) is encoded by the human IGF1 gene. This protein may be involved in the regulation of glucose metabolism. |
| DesignNote |
Elevated serum levels of insulin-like growth factor-1 (IGF-1) may identify premenopausal women who are likely to develop breast cancer before age 50. (Int J Cancer. 2000; 88: 828-832, via Medscape) Similar to insulin, the full length insulin-like growth factor I precursor protein is cleaved at positions 48 and 188 to release a 70 amino acid growth factor and a 77 amino acid E peptide. (UniProt) |
| Display_Name |
Insulin-Like Growth Factor I |
| FULL_SYN |
Mechano Growth Factor Somatomedin C Insulin-Like Growth Factor-I Insulin-Like Growth Factor I Somatomedin-C IGF I IGF-I Insulin-Like Growth Factor 1 IGF1 IGF-1 MGF |
| label |
Insulin-Like Growth Factor I |
| Legacy Concept Name |
Insulin-Like_Growth_Factor-1 |
| OMIM_Number |
147440 |
| Preferred_Name |
Insulin-Like Growth Factor I |
| prefixIRI |
Thesaurus:C16743 |
| prefLabel |
Insulin-Like Growth Factor I |
| Semantic_Type |
Amino Acid, Peptide, or Protein |
| Swiss_Prot |
P05019 |
| UMLS_CUI |
C3712803 |
| subClassOf |